| Objective: to understand the relationship of Plasma hypersensitive C-reactive protein(hs-CRP) level between Parkinson’s disease (PD) patients and healthy controls. inXinjiang Urumqi area; at the same time to explore the factors related to the PD, to providea basis for further study of the cause and treatment of PD. Methods: PD epidemiologicalinvestigation to the resident population of Xinjiang in Urumqi, according to the UK PDSociety Brain Bank Clinical Diagnostic Criteria[1]diagnosis of126cases of PD patients,according to age, gender, ethnic group, etc. using the case-control study method, selected120cases randomly into the control group. general physical and neurologic examinationsfor each candidate; at the same time to complete the determination of plasma hs-CRP.Results:1. in sample population the plasma hs-CRP levels of PD patients is (1.16±1.19mg/dl) higher than that of the control group (0.38±0.22mg/dl), there was significantdifference between them(P<0.001). At the same time, the level of hs-CRP in plasma ofUygur PD patients (1.35±1.48mg/dl) is higher than that of the control group (0.42±0.25mg/dl), there was significant difference between them (P<0.001); the level of plasmahs-CRP in Han PD patients (1.10±1.09mg/dl) is higher than that of the control group(0.36±0.22mg/dl), there was significant difference between them (P<0.001).2. plasmahs-CRP level of PD patients in different sex (1.08±0.74mg/dl,1.36±1.31mg/dl), anddifferent ethnic groups (1.09±1.08mg/dl，1.35±1.48mg/dl), there was no significantdifference (P>0.05). according to the years of PD, divided PD patients into3groups,plasma hs-CRP level was no significant difference between the0-5years group,5-10years group,10-15years group (P>0.05).Conclusion: the levels of plasma hs-CRP of the survey population was related to PD; elevated hs-CRP maybe one of an risk factor of PD;nerve inflammation may be an important factor in the pathogenesis of PD. |
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