Study On The Association Between C-reactive Protein Levels In Plasma And Parkinson’s Disease

Objective: To conduct a comparison study of C-reactive protein (CRP) in plasmaof Parkinson’s disease (PD) patients and normal populations, and to explore its clinicalsignificance.Methods:We selected PD patients with a total of40cases from April2010toDecember2011in Dalian Friendship Hospital.The levels of CRP among PD and controlgroup were examined.The relationship among CRP levels and PD severity,PD duration,age, cognitive function and mood status were analyzed.Results:(1) PD group had an elevated plasma CRP levels compare to the controlgroup, the difference was statistically significant (P <0.05);(2)The relationship ofplasma CRP levels and UPDRS III score system, H-Y staging and MMSE score systemin PD group: plasma CRP levels and UPDRS III score system was significantlycorrelated (r=0.709, P <0.01); plasma CRP levels and H-Y stage was significantlypositively correlated (r=0.677, P <0.01); plasma CRP levels and MMSE score systemwas not correlated(r=-0.147, P>0.05);(3) The group which disease duration wasgreater than4years(≥4years group)had a higher plasma CRP levels than the groupwhich disease duration was smaller than4years(＜4years group) in PD group,thedifference was statistically significant (P <0.05);(4) The group which the age wasgreater than60years(≥60years group)had a higher plasma CRP levels than the groupwhich the age was smaller than60years(＜60years group) in PD group,the differencewas statistically significant (P <0.05);(5) The relationship of plasma CRP levels andmentality: there is no significant differences with plasma CRP levels in patients ofanxiety and depression respectively(P>0.05).Conclusion: Plasma CRP levels are closely related to severity and duration and age in PD group. And there were no significant corrections between CRP and cognitivefunction and anxiety, depression. We suggest that our results could support that thehypothesis that neuroinflammation contributed to the pathogenesis of PD, anddemonstrate that CRP can be used to predict the severity of PD disease,and provide thebasis for the anti-inflammatory treatment of PD.