The Relationship Of The Serum Resistin Level And Oxidative Stress In Patients With Metabolic Syndrome Among The Urgur And Han Adults Lived In Xinjiang

Objective：The aim of this study was to investigate the relationship between serumresistin levels and oxidative stress with markers of the Metabolic Syndrome, and played arole in the pathogenesis of MS among the adults lived in Xinjiang. Methods：Data fromthe dietary and metabolic disease risk survey study of1333people aged35to75years oldfrom july2011to july2012both Urgur and Han adults lived in Xinjiang. All the subjectswere diagnosed according to the the International Diabetes Federation (IDF) criteria forMS, a total of50patients with metabolic syndrome (case group) were selected from MS,and50normal control subjects (normal group) were matched with case group in age, sexand ethnic also come from the same place, serum resistin level and oxidative stressindictaors among case and normal groups were measured in laboratory. Results：①Theprevalence of MS was35.33%,36.62%and34.41%in male and female population；②Theprevalence of MS was39.62%,32.60%in Uygur and Han. There was no significantdifference in independent samples test (P＞0.05)；③The BMI, WC, WHR, blood pressure,TC, TG, LDL-C, FPG, FINS, HOMA-IR, serum resistin and MDA were significantlyhigher (P<0.05) in subjects with MS when compared with subjects without MS. While theHDL-C, SOD and GSH-PX levels were lower in subjects with MS when compared withsubjects without MS (P<0.01); Moreover, the level of SOD in normal group wassignificantly higher (P<0.05) in Uygur when compares with subjects in Han，the otherindexes no significant difference between them in case and normal groups (P＞0.05);④Correlation analysis of resistin, oxidative stress and the risk of MS, serum resistin levelswere positively associated with BMI, WC, WHR, blood pressure, TC, TG, FINs, HOMA-IR and MDA (allP<0.05), negatively associated HDL-C, GSH-PX and SOD (P＜0.01) in case group;⑤Logictic regression analysis showed that WC, MDA andHOMA-IR were the independent risk factors and GSH-PX was the protective factorassociated to MS, but resistin was not correlated in MS. Conclusion:①Compared tonormal group, serum resistin of MS were significantly higher, but there was no significantdifference in Uygur and Han;②For patients of MS, serum resistin levels increased andantioxidant levels reduced, which showed patients of MS were in oxidative stress status;③Correlation analysis showed that resistin concentration was closed with in MS patients,thus suggesting the correlation of resistin with the determinants of MS;④Logicticregression analysis showed that WC, MDA and HOMA-IR were the independent riskfactor and GSH-PX was the protective factor associated to MS;⑤Resistin may activateoxidative stress system as a indirect index of MS through abdominal obesity, to affectpathogenesis of MS, but the specitic mechanism of resistin need further study.