The Study Of The Relationships Of The Serum Resistin, Leptin Level And Insulin Resistance In Patients With Metabolic Syndrome

Objective To investigate the relationships between the serum resistin level , leptin level and lipid level, obesity and insulin resistance in patients with metabolic syndrome.Methods ELISA was used to examine the fasting serum resistin and leptin in 60 metabolic syndrome male patients who were divided into obesity group and non-obesity group according to body mass index(BMI)and 28 age-matched normal control subjects. At the same time their height, weight, waist circumstance, hip girth, blood pressure, blood glucose, blood lipid, insulin, BMI, waist to hip ratio(WHR) and insulin resistance index(HOMA-IR) were measured.Results In comparison with the control, the obesity group of metabolic syndrome had higher serum resistin level(28.28±11.7μg/L VS 19.44±5.79 μg/L, P<0.01)and higher leptin level (1.47±0.57 μg/L VS 0.31±0.13 μg/L, P<0.01). The non-obesity group of metabolic syndrome had also higher serum resistin (26.14±11.9μg/L VS 19.44±.79 μg/l, P<0.05) and leptin level (1.35±0.57μg/L VS 0.31±0.13μg/L, P <0.01) than the control group. But there were no significant difference in serum resistin and leptin level between the two groups. Correlation analysis demonstrated that the fasting serum resistin level was positively correlated with WHR, the fasting serum insulin level and insulin resistance index(r=0.22,r=0.22,r=0.19; P <0.05)and was positively correlated with BMI, waist circumstance, hip girth and leptin (r=0.31,r=0.32,r=0.36,r=0.28; P <0.01), but negatively correlated with high-desity lipoprotein cholesterol(r=-0.24; P <0.05)and not correlated with systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, low-desity lipoprotein cholesterol and blood glucose.Correlation analysis also demonstrated that me fasting serum leptin level was positively correlated with BMI, waist circumstance, hip girth, WHR, systolic blood pressure, diastolic blood pressure,triglyceride ,the fasting serum insulin level and insulin resistance index (r=0.59,r=0.64,r=0.53,r=0.64,r=0.47,r=0.53,r=0.49,r=0.39,r=0.32; /><0.01)and was positively correlated whk blood glucose (r=0.23; P <0.05), but negatively correlated with high-