A Systematic Review Of The Published RCTs Was Used To Compare The Success Rates Of Remnant Thyroid Tissue Ablation Using Low Dose Or High Radioiodine Dose

Objective: A systematic review of the published RCTs was used to compare thesuccess rates of remnant thyroid tissue ablation using low dose (approximately30mCi)with high dose (approximately100mCi). Methods： CNKI（1986~2012）、Wanfangdata（1986~2012）、VIP（1989~2012）、Cochran liberty、OVID（1986~2012）、Pubmed（1986~2012）、EBSCO（1986~2012）、EMBASE（1986~2012）、Springer Link（1986~2012）、Science Direct（1986~2012） were searched for all the RCT about lowversus high radioiodine dose in postoperative ablation of the thyroid remnant indifferentiated thyroid cancer. Results:6RCTs were included.There is no statisticalsignificance in the ablation success rate during low and high radioiodine dose[OR=0.78,95%CI[0.58,1.06],P=0.11].The adverse effects of dry eyes were no statistical significancebe ween the two groups[OR=0.77,95%CI（0.53,1.12）,P=0.18]. Dry mouth was nostatistical significance during the two groups[OR=0.69,95%CI（0.47,1.01）,P=0.06].Nausea has statistical significance during of the two group.The incident rate in low dose islower than that in high dose[OR=0.32,95%CI（0.18,0.55）,P<0.0001].The incident rate ofpain in the neck in low dose is lower than that in high dose[OR=0.49,95%CI（0.31,0.78）,P=0.003]. conclusion: During postoperative ablation of the thyroid remnantin differentiated thyroid cancer,low radioiodine dose is worth spreading.