Expression And Significance Of MCP-1and MMP-14in Patients With STEMI

Objective: The aim of the study is to assess MCP-1, MMP-14plasma levels inpatients with STEMI. To discuss the role of MCP-1and MMP-14in patients with STEMI.To evaluate the correlation between MCP-1, MMP-14and MACE. Methods: Fiftypatients with STEMI were recruited from Nov2011to Jun2012in our hospital. Fiftypatient without significant coronary artery stenosis were recruited into the control group.The plasma levels of MCP-1and MMP-14were detected with Enzyme immunosorbentassay. The incidence of new or recurrent myocardial infarction, target vesselrevascularization, cardiac death, heart failure(MACE) was recorded during a follow-upperiod of6months.Results: Compared with the control group, the plasma levels ofMCP-1and MMP-14both elevated obviousely in the STEMI group(P＜0.05). MACEoccurred in10patients [(20%),10/50] during follow-up. Compared with the NON-MACEgroup, the plasma level of MCP-1elevated in the MACE group(P＜0.05). The plasmalevel of MMP-14elevated in the MACE group(P＜0.05). There is a positive correlationbetween MCP-1and MMP-14on admission.Conclusion: The plasma levels of MCP-1and MMP-14may have a diagnostic value of STEMI. They also may be a predicator ofshort-term risk of MACE.