Clinical Analysis Of260Cases Of Invasive Breast Cancer Blood Sugar, Blood Lipid Changes Before And After Chemotherapy

Objective:To investigate the changes of blood glucose,blood lipids before and after chemotherapyof Xinjiang Han260cases of invasive breast cancer.Method:Retrospective of patients with invasivebreast cancer were treated Xinjiang Medical University tumor Hospital from January2005toDecember2006,Organize their clinical data,Collect blood glucose,triglycerides,cholesterol data beforeand after chemotherapy,compare the variation of blood sugar,and blood lipids before and afterchemotherapy,characteristics of the metabolic syndrome occurs in clinical cases,clinical andpathological data.And domestic and international literature on the incidence of breast cancer afterchemotherapy,analysis and discussion of the etiology and pathogenesis-related risk factors, diagnosticcriteria, treatment and prognosis.Fand the regular pattern and related factors of glucose and lipidvariation in breast cancer after chemotherapy,Use on-conditional logistic regression analysis calculatedrisk odds ratio (OR) and95%confidence intervals (CI).Result: After Breast cancer chemotherapyDiabetes incidence4.23%,hypertriglyceridemia was2.69%.Hypercholesterolemia was1.92%.Singlefactor analyses:Bbreast cancer chemotherapy hyperglycemia associated with older age, menopause, useof corticosteroids, high body mass index was statistically significant (P>0.05)，Included in thenon-conditional logistic regression multivariate analysis，older age and the use of corticosteroidsdifference was statistically significant (P <0.05), menopause, high body mass index differences notstatistically significant (P>0.05);Univariate analysis after chemotherapy triglyceride, cholesterolincreased with older age, menopause, high body mass index was statistically significant (P <0.05). Beincluded in the non-conditional logistic regression analysis, the differences were statistically significant(P <0.05).Conclusion:Older age, using glucocorticoids are two independent risk factors of breastcancer patients who elevated blood glucose after adjutant chemotherapy.High body mass index,menopause, is unusual, kidney function is unusual is relative risk factors of breast cancer patients who elevated blood glucose after adjutant chemotherapy.Old age, high body mass index, menopause areindependent risk factors of breast cancer patients who elevated blood lipids after adjutantchemotherapy.