Expression Of Heat Shock Protein27in Patients With Gastrointestinal Tumors

Objective：To determine the positive expression and clinical significance of the heatshock protein27（HSP27）in common gastrointestinal tumors（esophageal cancer、gastriccancer、colon cancer）.Methods：Selected329small endoscopic biopsy specimens or bigpostoperative specimens from three regional triple A hospitals of Xinjiang in2008-2011.Including13cases of esophagitis,20cases of Barrett’s esophagus,12cases ofesophagus cardia adenocarcinoma,56cases of superficial gastritis,68cases of CAG andH-IN,20cases of antrum of stomach adenocarcinoma,40cases of colitis,50cases of colonpolyps,50cases of colon adenocarcinoma.Immunohistochemical SABC method was usedto examine the expression of HSP27in common gastrointestinal tumors.Results：(1)HSP27was detected in30.7%of esophagitis,75%of Barrett’s esophagus,91.7%ofesophagus cardia adenocarcinoma.The rate of the positive expression of HSP27in thesethree groups showed a trend of increasing (P<0.05);(2)HSP27was detected in17.9%ofsuperficial gastritis,47.1%of CAG and H-IN,90%of antrum of stomach adenocarcinoma.The rate of the positive expression of HSP27in these three groups showed a trend ofincreasing (P<0.05);(3)HSP27was detected in5%of colitis,84%of colon polyps,96%ofcolon adenocarcinoma.The rate of the positive expression of HSP27in these three groupsshowed a trend of increasing (P<0.05).(4)Positive expression of HSP27relationship withgender,age,nationality had no statistical significance (P>0.05).Conclusion：Excessiveexpressed of HSP27and esophagus cardia adenocarcinoma、 antrum of stomachadenocarcinoma、colon adenocarcinoma had correlation.Therefore,these3kinds of heatshock proteins will be used to guide the clinical treatment and research tumor vaccinefuture.