Prognostic Factors Analysis Of Central Venous Catheter Related Bloodstream Infections In Intensive Care Unit

Central venous catheters were now widely used for fluid infusion, haemodynamic monitor, parenteral nutrition and hemodialysis in critically ill patients. However, Central venous catheter related bloodstream-infection also became one of the most severe risk factors in nosocomial infection, which associated with substantial increased hospital cost and length of stay.For those patients who diagnosed as CRBSI, figuring out risk factors of CRBSI mortality would help clinicians to increase treatment effect and reduce hospital mortality. Thus, we conducted this retrospective study aiming to investigate the mortality predictors for those infected patients.Objective:To investigate the mortality predictors for those patients who diagnosed as CRBSI.Methods:We conducted a retrospective study of all patients diagnosed as CRBSI in ICU from a period from November2010to November2012. Clinical and physiological features of survivors and non-survivors were compared and analyzed. Meanwhile, data of catheter management, including catheter dwelling duration, time interval from infection to catheter removal, were also collected for analysis. Multi-logistic regression analysis was introduced to investigate the potential prognostic risk factors of mortality.Results:From November2010to November2012,49cases of CRBSI were available for our review, in which40cases survived (81.6%) and9cases (18.4%) died in the hospital. Univariate analysis showed statistic differences in age, blood lactate, blood platelet count, activated portion of the blood coagulation time, serum albumin, glutamic oxalacetic transaminase, lactate dehydrogenase, creatinine, urea nitrogen, C-reactive protein levels, incidence of hypotension and time interval from infection to catheter removal between survivors and mortality group(P<0.05). Multi-logistic regression analysis indicated that elderly age, low serum albumin and delay in catheter removal was predictors of worse outcome.Conclusions:Advanced age、low albumin level and delay in catheter removal might be predictors of poor pognosis of CRBSI patients, which need to arouse more concerns.