The Relationship Between Epicardial Adipose Tissue Thickness And Coronary Artery Disease

[Background] Coronary artery disease is a significant cardiovascular disease threatening tothe health of the middle-aged.Latest evidences indicate epicardial adipose tissue thicknessmight be a critical risk factor of coronary artery disease.The coronary artery inflammationcan be stimulated form the outside to inside,and the epicardial adipose tissue might serveas a therapeutic target for the disase.[Objective] To investigate the relationship between epicardial adipose tissue thickness andthe pathogenesis,risk factors and severity of coronary artery disease,which can furtherguide the clinical application.[Methods] Randomly select patients in our hospital who simultaneously underwentcoronary angiography and chest computed tomography.According the diagnosis standard ofcoronary artery disease,divide the patients into two groups:coronary artery disease groupand non-coronary artery disase one.Then,respectively record the data of two groupsincluding the angiography result, the epicardial adipose tissue thickness measured bycomputed tomography,the laboratory and other general information.Finally,sort out themand make a statistic analysis. [Results] The epicardial adipose tissue thickness of the coronary artery disease group issignificantly higher than the non-coronary artery disease group(9.26±2.0mm vs.5.63±1.00mm,p<0.01).Significant correlation between the epicardial adipose tissuethickness and the disease risk factors including body mass index and age(r=0.597,r=0.482,p<0.01).In the coronary artery disease group,the thinckness significantly correlateswith the Gensini’s score（r=0.911,p<0.01）, increasing with the severity of coronary arterystenosis.[Conclusion] Epicardial adipose tissue might be a critical independent risk factor ofcoronary artery disease,which also might serve as a therapeutic target for the disease.