The Relationship Of Epicardial Adipose Tissue Volume And Coronary Artery Calcification Score On CT Measurement With Coronary Artery Stenosis

Objectives 1 To investigate the association of epicardial adipose tissue volume( EATV) with coronary artery atherosclerotic plaque. 2 To investigate the clinical application value of epicardial adipose tissue volume( EATV) and coronary artery calcification score(CACS)to predict coronary artery stenosis.Methods There were 201 patients who underwent CT coronary angiography(CTA)examination were divided into the case group and healthy control group. All the subjects were divided into different groups according to the results of CTA and patients age in the case group. All the axis images of coronary vessel were transferred to the syngo.via workstation to analysis afte CTA scan by 64-slice spiral CT( SIEMENS definition4.0)retrospective ECG-gating technique each branch vessel and total vessel CACS was measured and calculated though the CACS software. In addition, measurement of EATVand the total voloum(TV)of the region of interest and Hounsfield unit(HU)through CT measurement tools. All the data was collected and analyzed using Excel2003 and SPSS13.0. Independent t test and ANOVA analysis were used to analyze the difference of 2 groups, 3 and more groups. Spearman correlation analysis was used to analyze the correlation of EATV, CACS with various coronary artery lesions. Receiver operating curve(ROC) was used to analyze the diagnostic efficacy of EATV and CACS to predict coronary artery stenosis. Count data using chi square test,it was used to analyze sensitivity,specificity and accuracy of through EATV and CACS to predict coronary artery stenosis.(P<0.05(bilateral) for signification differences in all of dates.).Results 1 There was a significant positive correlation between EATV and CACS with types of plaque, CACS groups, numbers of lesions(P=0.005, 0.001, 0.007). 2 There was a significant positive correlation between EATV, CACS with stenosis( r=0.226,0.667; P=0.001, <0.001); The area under the ROC curve of EATV and CACS to predict the presence of stenosis were AEATV=0.632,ACACS=0.863,(P=0.001, <0.001).3 Taking CACS>0,EATV≥97ml as the diagnostic criteria of detect coronary stenosis, the positive predictive value and ngative predictive value of EATV were 73.07%,56.70%,respectively; the positive predictive value and ngative predictive value of CACS were93.87%,74.75%, respectively; the positive predictive value and ngative predictive valueof EATV+CACS were 98.91%,75.22% respectively. The sensitivity, specificity and accuracy of EATV to detect stenosis were 64.40%, 66.30%, 65.17%; The sensitivity,specificity and accuracy of CACS to detect stenosis were 77.96%, 92.80%, 84.07%; The sensitivity, specificity and accuracy of CACS + EATV to detect stenosis were 77.11%,98.80%, 86.06%. 4 The area under the ROC curve of EATV to predict the presence of stenosis in the cases of CACS=0 were AEATV=0.647(P=0.026).Conclusions 1 There was a significant positive correlation between EATV and CACS with types of plaque, CACS groups, numbers of lesions.2 There was a significant positive correlation between EATV, CACS with stenosis. There was clinical value of EATV and CACS for the diagnosis of coronary artery stenosis, while the diagnostic efficacy of EATV was not as good as CACS. 3 When CACS>0、EATV≥97ml, Thespecificity and accuracy of CACS + EATV to detect stenosis were higher than EATV and CACS, while the sensitivity was lower than CACS. 4 EATV could predict coronary artery stenosis in the case of no coronary calcification..