| Objective：To discuss the role of chemokine CCL17and chemokine receptor CCR4inpathogenesis of mycosis fungoides by examing the expression of CCL17and CCR4inpatients skin lesions with MF, as well as to look for new therapies for the disease.Methods：By immunohistochemistry Elivision method, I investigated the expression ofCCL17and CCR4in pafarrin sections of12MF patients skin lesions which were collectedform2003to2012in outpatient department and compared the data with12patients withpsoriasis vulgaris and12healthy controls. Then, all sections were scored both dependingon the proportion of positive cells and degree of dyeing. I analyzed the results with the helpof the SPSS soft.Results：1.All the12MF lesions were CCL17positive with7samples strong expression(it was detectable in epidermal keratinocytes), which was significantly higher than thepsoriasis samples and the normal prepuce tissues (p<0.05); but there was no significantdifference between the psoriasis and the normal prepuce.2..All the12MF lesions wereCCR4positive and a significant elevation was observed in the expressions of CCR4(it wasdetectable in dermal infiltrating T cells) in the MF lesions than that in the psoriasis lesionsand the normal prepuce tissues (p<0.05); meanwhile, a significant difference was foundbetween the psoriasis lesions and the normal prepuce tissues (p<0.05).Conclusion：Comparing with the nontumorous inflammation skin lesions and the normal skin, the expression of chemokine CCL17and its receptor CCR4was increased in MFlesions. CCL17and CCR4took part in the pathogenisis of MF through mediating theskin-homing of dermotropism T lymphocytes. |
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