The Study Of Repair Rabbit Radial Bone Defect With Bone Tissue Engineering SF/CS/nHA Three-dimensional Scaffold

Objective: to study the capacity and mechanism of composite scaffold material repairbone defectMethods:45New Zealand white rabbit were randomly divided into A group(SF/CS/nHA group), B group (SF/CS group)and C (blank contrastgroup)group.Establish annimal model which the rabbit right radial bone defect byoperation.group A SF/CS/nHA composite scaffold were implanted in bone defect asexperimnt group.group B SF/CS composite were implaned in as contrast goup.group Cimplant nothing as blank contrast group.After the surgery. X-ray radiography wasperformed after4,8,12,16weeks.the rabbit were sacrificed accordingly for generalobservation and histopathological observation.Estimate the osteogenesis effect andmechanism.Result and conclusion:4weeks after surgery experimental group shows higher bonemineral density than control group. Pathology slices showed normal bone tissue partlyreplace the scaffold materials.8weeks postoperatively experimental group close tonormal bone mineral density. pathological slices showed in experimental group scaffoldwere Basicly replaced by normal bone tissue.12to16weeks after surgery X-ray andhistological observation showed the experimental group were completely replaced bythe normal bone tissue, the bone marrow cavity was rehabilitated. contrast group bonemass is lower than the experimental group. Blank group were filled by fibrous connectivetissue. SF/CS/nHA composite scaffold materials is expected to become the ideal bonetissue engineering scaffolds.