Efficacy And Tolerability Of Tolterodine SR In Patients With OAB Complaints Secondary To Uncomplicated Lower Urinary Tract Infection (After Antibiotic Treatment)

[Objective] To study the efficacy and tolerability of tolterodine SR in patients with OAB complaints secondary to uncomplicated lower urinary tract infection after antibiotic treatment,and to compare the effect of two groups in order to guide the clinical practice.[Method] Randomized controlled trial and open study will be used in the clinical drug experiment.The study recruited female patients who conform to the inclusion criteria not the exclusion criteria. Treatement in patients was divided into two phases.The patients were treated with antibiotics which is belong to a kind of quinolone drugs for three to five days in the frist phase. A total of61patients who had been selected were randomly divided into a experimental group(Tolterodine SR,4mg/d) and a control group.(Blank control group). Routine of urine and OABSS was used as objective evaluation indicators.In the first phase,all the subjects who had been screened into groups were treated with a short-term antibiotics,and a series of score datas were recorded. In the secend phase, the researchers followed-up patients in the experimental group and the control group in the end of the first week,the second week,and the fourth week after grouped.The clinical research followed-up for5periods,OABSS and adverse reactions were recorded in every period,and OABSS was analysed between the experimental group and the control group by using an analysis of t-test through the software of SPSS13.0.[Result] A total of61patients were sellected during September2012through March2013and were followed-up,31patients in experimental group and30patients in control group.OABSS score of the experimental group was8.71±1.553in the screening stage, 7.84±1.440after treated with antibiotics for a short-time,6.45±1.287after1week by using tolterodine SR,5.71±1.575after2weeks by using tolterodine SR,5.68±1.492after4weeks by using tolterodine SR.OABSS score of the control group was8.70±1.512in the screening stage,7.73±1.437after treated with antibiotics for a short-time,8.03±1.402after1week without using any drugs,8.23±1.547after2weeks without using any drugs,8.30±1.466after4weeks without using any drugs.There was no significant difference of age between the experimental group and control group by using paired sample T test. The comparison of OABSS score between two groups showed significant difference in the frist week,the second week, the fourth week after randomization.There was significant difference of OABSS score among any two follow-up period except the OABSS score between the second week and the forth week though the comparison in the experimental group to each other.Among any follow-up period after randomization in the control group without any treatment measures in participants,there was no significant difference of OABSS score.The following adverse events occurred during the period of using tolterodine SR,1patient had to terminate the use of drugs because of the dizziness,31cases in the experimental group completed all of the follow-up process,22cases of all accompanied with adverse reactions which mainly performed with dry mouth, dizziness, constipation.These clinical symptoms do not interfere with continued after evaluation,and there was no withdrawal due to adverse reflect.[Conclusion] Tolterodine SR effectively improved OAB complaints secondary to uncomplicated lower urinary tract infection after antibiotic treatment.After two weeks treatment of Tolterodine SR, the improvement of the OAB symptoms scores could achieve the best effect.