Study On Anti-mullerian Hormone Joint Follicular Output Rate In In Vitro Fertilization-embryo Transfer

OBJECTIVE:To improve the guidance of IVF-ET treatment.We study the clinical value ofserum AMH joint follicular output rate(FORT) in IVF–ET by analysing therelationship of clinical outcome indexs with serum AMH level,FORT and thecorrelation between the two in the patient undergoing IVF–ET。METHOD:The204cases of patients are recruited who conform to the standard and askingIVF–ET treatment in our hospital from May2012to October2012. The level ofAMH, FSH, E2in blood are measured and the number of antral follicle are countedon the second day of menstrual cycle after accomplishing the examination. Thepatients are injected gonadotropin-releasing hormone agonist3.75mg on the day. ByUltrasound evaluate the follicle number whose diameter from2to8mm on the r-FSHadministration day. HCG administration day count the number of preovulatoryfollicle.Calculate the FORT. Analyse the relationship of clinical outcome indexs withserum AMH,FORT levels and the correlation between the two are analysed. Thenrespectively according to the serum levels of AMH and FORT size low, middle andsenior group are divided.Then comparison between groups of primary data andclinical outcome indexs. To assessment the value of serum AMH level combinedFORT in IVF–ET.RESULT:(1) The basic serum AMH level is negative relation with age and basic FSH ispositive relation with basic E2level, the number of antral follicle and oocytesretrieved. The number of oocytes retrieved and AMH level correlation coefficient isthe biggest in all predictors.which is0.811;(2) The fertilization rate and top qualityembryo rate of the serum AMH level highest group (Hg) are more lower than the twoother groups (62.3%VS65.9%,66.9%and27.3%VS33.4%,34.5%).The difference is statistically significantly (P <0.05), And the implantation rate and clinical pregnancyrate has no statistically significantly difference in3groups. The moderate、severeOHSS rate are statistically significantly difference in3groups (P <0.01);(3) Thelevel of FORT and AMH are negative correlated, The correlation coefficient is-0.612, The fertilization rate and top quality embryo rate of3groups whose level ofFORT from low to high are61.3%,63.8%,68.2%and26%,31.6%,37.4%Thedifference are statistically significantly (P <0.05); The implantation rate and clinicalpregnancy rate has no statistically significant difference in3groups.CONCLUSION:(1) The FORT is negative related to the basic AMH and combine both can guidethe treatment of IVF–ET.(2) The basic AMH is better than the current clinicalindexes used for evaluation of ovarian reserve;(3) The AMH predict clinical outcomeof IVF-ET treatment remains to be further study;...