In Utero Exposure To Organophosphate Pesticide And Neonate Neurobehavior Development

Pesticides are widely used in China, which more than a third of is organphosphorus pesticides (OPs).Due to the excessive use of pesticides and high residue, thecrowd on OPs common exposure through food. According to the literature report,pregnant women, children and other people have become the exposed sensitive crowd toOps. Animal experiments have found the prenatal exposure to OPs lead to neurotoxicity,but the study of the in utero exposure to OPs and neurodevelopment in neonates werestill limited and inconsistent. This research through the cooperation with Shanghaimunicipal center for disease control and prevention, Using gas chromatography (GC) indetection of OPs metabolites (DAPs), alkyl phosphate ester compounds can effectivelyreflect accurately the body of low dose exposure levels in the body during pregnancyand the risk assessment of neonatal neurological development laid a solid foundation.This study adopts the method of epidemiological status of research, at the center ofthe Shenyang medical school affiliated hospital childbirth maternal and newborn healthas the research object, collect the maternal urine samples before delivery, and used forthe determination of organ phosphorus pesticide metabolites in the body, in usingNeonatal birth3days20NBNA evaluation of neonatal neurobehavioral developmentsituation. This study used gas chromatography determination in five kinds of organphosphorus pesticide and the urine metabolites (DAP); five analytes were measured ineach sample: DMP, DMTP, DEP, DETP. In Shenyang in maternal body OPs cumulativeexposure levels were evaluated, and discuss the influence factors and risk assessment ofthe effect of neonatal neurological development. Studies have shown that202maternalpregnancy urine metabolites of Ops detection rate from92.89%(DEP) to5.2%(DEDTP).The maximum value without creatinine adjustment was334.02μg/L for DMP,167.06μg/L for DEP,137.95μg/L for DMTP,133.0μg/L for DETP and2.49μg/L for DEDTP；The GM values without creatinine adjustment for DMP, DMTP, DEP andDETP levels were18.03,8.53,7.14, and5.64μg/L, respectively; the GM for DEDTPlevels was not calculated because of low detection frequency.Compared with the DAPs among the pregnant women, the level of DMs and DEsof the pregnant women aged more than thirty years old were significantly higher thanothers (P＜0.05); There were significantly negative correlation between DAPs andNBNA scores (P＜0.05). The scores of NBNA, including the Summary, behavior,passive tone, active ton, primary reflexes, of the pregnant women high exposure to OPswere significantly lower than those lower exposure to Ops (P＜0.05).In summary, Over30maternal body organophosphorus pesticide exposure agematernal exposure level slightly higher than others in Shenyang,prompt age may be arisk factor for organophosphorus pesticide exposure.Maternal organophosphoruspesticide exposure levels associated with neonatal neurobehavioral development.organophosphorus pesticide exposure during pregnancy may be a risk factor fordevelopment of the nervous system in the newborn,Namely,the higher the level oforganophosphorus pesticide exposure during pregnancy may be more adverse to thenewborn neural development.The study on Shenyang maternal body cumulative exposure of OPs conducted apreliminary assessment, and explore the OPs exposure during pregnancy on neonatalneurological development, in order to carry out extensive prenatal OPs exposure levelmonitoring, set for the domestic women of childbearing age long term exposure to OPssafety limits provide a scientific basis.