Choroidal And Retinal Thickness Measurements And The Relevant Factors In High Myopia Amblyopic Chinese Children Eyes

ObjectivesTo compare posterior choroidal thickness and retinal thickness in high myopia amblyopia eyes at different points to normal, low myopia, medium myopia and high myopia eyes using enhanced imaging (EDI) optical coherence tomography (OCT) in Chinese children. Relationships between choroidal thickness and retinal thickness of high myopia amblyopia, age, refractive error and axial length were investigated.MethodsSeventy-five Chinese children (129eyes) with a mean age of (10.31±3.03) years were recruited. By atropine optometry after they were divided into: normal (22eyes), low myopia (38eyes), medium myopia (22eyes), high myopia (22eyes), high myopia amblyopia (25eyes). Choroidal and retinal scans were obtained for all eyes using enhanced depth imaging spectral-domain optical coherence tomography. Subfoveal choroidal thickness (SFCT), macular thinkness, choroidal thickness and retinal thickness at0.5mm/1.0mm/1.5mm/2.0mm/2.5mm/3.0mm nasal, temporal, superior, and inferior to the fovea were measured. Meanwhile axial length, best-corrected VA, and refraction were also survey. The Nonparametric test of compltely randomized design and multiple comparisons were used to analyze differences locations in choroidal thickness and retinal thickness. A Pearson correlation was calculated for variation in choroidal thickness relative to ocular axial.Results1. The average subfoveal retinal thickness was (218.3±17.3)μm in high myopia amblyopia and in normal, low myopia, medium myopia, high myopia with no statistical difference (P=0.053).2. Outside the retinal thickness fovea of high myopia amblyopia, in nasal, temporal, superior, and inferior mean CT which this measurement was significantly thinnest than the same location in normal, low myopia, medium myopia, high myopia (P≤0.02).3. There were no correlation among average subfoveal retinal thickness and axial length, refraction status, age in high myopia amblyopia.4. The high myopia amblyopic children of the average choroidal thicknesses were176.8±65.7μmat the fovea, and this measurement was significantly thinnest than the subfoveal CT of normal, low myopia, medium myopia, high myopia (P<0.05). Outside the fovea of high myopia amblyopia, in nasal, temporal, superior, and inferior average CT which this measurement was significantly thinnest than the same location in normal, low myopia, medium myopia, high myopia (P<0.001).5. In high myopia amblyopia, the temporal choroid is the thickest. The nasal choroid is the thinnest. The inferior and nasal choroids are the thinner, the further it are from the fovea. The superior and temporal choroids are the thicker, the further it are from the fovea.6. Choroidal thickness showed a negative correlation with axial length for the subfoveal location in high myopic amblyopia.7. There was no correlation between the average subfoveal choroidal thickness and age in high myopia amblyopia (R2=0.124, F=7.476, P=0.013).Conclusion1. The subfoveal retinal thickness in high myopic amblyopia was no statistical difference than normal, low myopia, medium myopia, high myopia. Outside the fovea of high myopia amblyopia, in nasal, temporal, superior, and inferior mean CT which this measurement was significantly thinnest than the same location in the any another teams. The subfoveal retinal thickness and axial length, refraction status, age no correlation.2. The choroidal thickness in high myopic amblyopia was significantly thinnest than normal, low myopia, medium myopia, high myopia. The subfoveal choroidal thickness and showed a negative correlation with axial length.