Expression And Clinical Significance Of RhoC And IQGAP1in Colon Cancer

Objective：To Study the expression and their correlation of RhoC (Ras homologous C)and IQGAP1(IQ motif containing GTPase activating protein1) protein in coloncarcinoma,for discussing their role and clinical significance in the development ofcolon cancer, and preliminary study correlations in colon cancerMethod：We collecte80patients paraffin samples of operation cutting for coloncancer during January2011-December2011at the First Affiliated Hospital ofBengbu Medical College. Immunohistochemistry(SP method) measured theexpression of RhoC and IQGAP1protein in colon carcinoma tissues. With30cases ofparacancerous tissues as control group, analysing the correlation of the two factorsand the relationship between colon cancer and prognosis.Results：1. RhoC and IQGAP1expression in colon cancer rate was66.25%(53/80) and71.25%(57/80), respectively, higher than the paracancerous tissues, and thedifference was statistically significant.2. RhoC expression in colon cancer is closely relate to TNM stage, lymph nodemetastasis and differentiation (P <0.05), but not to gender, age, tumor size (P>0.05)3. IQGAP1expression in colon cancer is closely relate to TNM stage, lymph nodemetastasis and differentiation (P <0.05), but not to gender, age, tumor size (P>0.05)4. A positive correlation is observed between the expression of RhoC and that ofIQGAP1in colon cancer (r=0.598,P <0.001).Conclusions:1. Both of RhoC and IQGAP1expresse highly in colon cancer tissue and are closelyrelated with the process of colon cancer happen，invasion and metastasis．2. RhoC and IQGAP1may have synergy effect on the process of invasion and metastasis in colon cancer．3. Jointly detecting both of RhoC protein and IQGAP1protein may have a certainreferencevalue in clinical stages and prognosis of colon cancer．...