The Relationship Between Different Bile Acid Levels And Perinatal Outcomes In Early-onset Intrahepatic Cholestasis Of Pregnancy

Objective：To evaluate the relationship between different serum totalbile acid (TBA) levels and perinatal outcomes in early-onset intrahepaticcholestasis of pregnancy (ICP).Methods：Fifty-seven cases of early-onset ICP, which were diagnosedby our hospital during the last6years, were included in this study. Theirclinical data were retrospectively reviewed.Results：These57early-onset ICP cases occupied0.22％(57/26261)of all the maternity inpatients during the study period. The levels of totalbilirubin (BIL), alanine aminotransferase (ALT) and aspartateaminotransferase (AST) in severe group were significantly higher thanthose in mild group （P<0.05）. The average neonatal birth weight in severegroup was lower than that in mild group [(2981±308) g vs (3192±327) g，P<0.05) and the delivery gestational age in severe group was shorter thanthat in mild group[(35.1±2.2) weeks vs (36.8±1.4) weeks， P<0.05]. Significant difference can be found between severe group and mild groupin meconium staining of amniotic fluid rate (33.3%vs12.1%, P<0.05) andcaesarean section rate (100%vs84.9%, P<0.05).The preterm birth rate（50.0%vs30.3%）, neonatal asphyxia rate （29.2%vs12.1%） andintrauterine fetal death rate （4.2%vs3.0%） showed no significantdifference between severe group and mild group.Conclusion： Severe ICP is more common in early-onset ICP andthe possibility of disadvantageous perinatal outcomes is high, suggestingmore attention should be paid to early-onset ICP.