Clinical Effect Evaluation Of Ning Dong Ranule On Tourette’s Syndrome

Objective:Evaluation of the clinical effect and security of ND granule onTOURETTE’S SYNDROME.Methods:85children were divided into Ningdong granule group and control groupby a randomized computer-generated code，Ningdong granule group has42peoples,controlgroup has43peoples. ND granule group were assigned to receive NDG3grams each timeunder the age of6or5grams each time above the age of7,2times a day，for6months.Patients in the Control group were started at a dose of1.0mg/d and increased in0.5mg/day increments every5days to a maximum tolerated dose of2-4mg/d,for6months.Itis best to both clinical curative effect, and does not appear obvious side effects.In order toinvestigate the effect of ND granule and Hal on TS, According to Yale Global TicSeverity Scale (YGTSS）,the severity of tics were evaluated at baseline and at end point.To evaluate the security of ND granule and Hal on TS, Side-effects were evaluatedaccording to an adverse event chart produced by this study team. aspartate transaminase(AST), Alanine transferase (ALT), blood urea nitrogen (BUN), creatinine, andelectrocardiogram were measured at baseline and at end point.Result:①In85TS’s children,2children in Ningdong granule and3children incontrol group put forward out of the study for personal reasons.At last,80childernparticipate in the test,Ningdong granule and control group each has40people.All subjectsin the two groups were similar with regard to age and gender.(P＞0.05).②Comparedwith Tourette’s syndrome of two groups before treatment, they had no significantdifference in the clinical aspects of tic symptoms.(P＞0.05).③In terms of age andcurative effect, the clinical effect of younger patients (3~6age) is better than old patients(7 ~14years and≧15years old) on Ningdong granule treatment of Gilles de la Tourette’ssyndrome.As a result,patients’s age is smaller, the clinical effect is better.④Compare withmain symptom scores of ND granule group and control group, Tourette’s total score ofpatients are decreased than before the treatment. Two kind of treatment can improvetourette’s syndrome.⑤Compared with YGTSS total tic score, YGTSS motor tic score andYGTSS vocal tic score at baseline, the scores of both two groups at end point reducedsignificantly (P <0.01). Compared with Control group, the YGTSS total tic score andmotor tic score in ND granule group reduced more significantly（P <0.05或P <0.01）. Thedifference of YGTSS vocal tic score reduction between the two groups was notsignificant.⑥The total effective rate (92.50%)in ND granule were higher than that(70.00%) in Control group (P <0.05).⑦the situation of improving T lymphocyte subsetshas significant difference between Ningdong granule group and the control group,(P<0.05).Ningdong granule can regulate the cellular immune function.⑧In the long-term follow-up,total effective rate in NDG group should be87.50%; The total effective rate in the controlgroup is57.50%At last, Ningdong granule group long-term effect is superior to westernmedicine group.⑨Security:Only2subjects reported loss of appetite and constipation in theND granule, while5subjects experienced adverse reactions, Somnolence, weak, dizziness,Extrapyramidal reactions, etc in Control group. The incidence of adverse reactions in NDgranule was lower than that in Control group. Moreover,no abnormalities on theliver,renal,Electrocardiogram and Routine blood tests were observed after administrationof two groups.Conclusion:ND granule could improve the syndrome of tics in TS. Morewhile it hasless side effects than Control group.