Prevalence And Correlates Of Depression In Patients With Upper Gastrointestinal Organic Diseases

Objective:Recent studies have demonstrated an increased number of patients suffering from gastrointestinal (GI) disorders are at primary risk for depression. The present study aims to investigate the prevalence of the comorbidity between depression and organic diseases of upper gastrointestinal tract (UGI).Methods:A total of707patients were reviewed using the nine-item Patient Health Questionnaire (PHQ-9). The PHQ-9scores≥10were further interviewed by psychiatrists using the criteria of Hamilton depressive scale (HAMD), Diagnostic and Statistical Manual of Mental Disorders,4th Edition (DSM-IV) to confirm the diagnosis.Results:412patients were found to suffer from organic diseases of UGI based on the gastroscopic results. Of these,83(20.15%) patients with PHQ-9score≥10and51(12.38%) patients were diagnosed with depression. The detection rate of major depressive disorder by gastroenterologists was3.92%. Logistic regression showed that the course of disease (P<0.001OR=1.011) number of gastroscopies (P=0.002OR=1.578)、age (P=0.001OR=0.918) and income (P=0.041OR=1.000) were significantly associated with depression.Conclusion:(1) The comorbidity rate between depression and organic diseases of UGI are high in GI patients in China. However, the detection rate of the comorbidity diagnosed directly by gastroenterologists is low.(2) Compared with the patients with upper gastrointestinal organic diseases, the comorbidity patients showed younger, longer disease course, higher educational status and income, more times of gastroscopy. And the disease course, income, times of gastroscopy were the risk factors of the comorbidity.(3)The rates of fatigue, insomnia and poor appetite were high in the patients of comorbidity.