Simulation To Comprehensive Effect Of Biodegradable Scaffold Performance In Bone Defect Repair Process

Bone tissue has complex structure and physiological mechanism. Using biodegradable scaffolds to repair bone defect is a fairly complex physiological process, controlled and influenced by multiple factors such as biological mechanism, mechanical stimulation, nutrition supply, scaffold structure, and the characteristics of biological materials. Study on multi-factor comprehensive effect to the process of repairing is to summarize previous work and prepare for repair process control and optimization.This paper mainly uses the method of computer simulation to research the comprehensive relationship between scaffold related factors and mechanical property of system in the process of repairing. Main work and achievements are as follows.1. A thought is proposed for stabilizing the mechanical property of bone-scaffold system in the process of repairing by designing internal pore structure layout of scaffold. Then formulate the corresponding technical route and simulation scheme. At the same time the use of the simulation platform is studied.2. A finite element simulation model about the process of bone defect repairing using biodegradable scaffolds based on cell is constructed, mainly including the basic mathematical model such as bone forming control equation, scaffold degradation control equation, the bone-scaffold coupling relation, and the evaluation of mechanical properties of the system as a whole. Some key technologies such as the discriminator of adjacent units and dynamic real-time describing and recording for process parameters are implemented.3. The simulation analysis of mass parameters is realized. The relationship between scaffold pore density and material strength is discussed, as well as scaffold structure. The tips for designing and manufacturing bone tissue engineering scaffold are summarized.This article preliminary confirms the feasibility of stabilizing the mechanical property of bone-scaffold system in the process of repairing by designing internal pore structure layout of scaffold based on the work above. Further research needs to be validated by cell culture and animal experimentation.