| Background: Corpus callosum is located at the base of the longitudinal crack on thebrain’s generous fiber bundle plate, connecting the left hemisphere of transverse nervefiber bundle, is the biggest of the cerebral hemisphere commissural fibers. Is mainlyresponsible for information exchange and integration between hemispheres hemisphereactivity on both sides, including both hands movement, unified feeling, memory andretrieval, language and hearing function, especially for visual information transfer hasan important significance. Past research in the general form of the corpus callosum, withthe development of magnetic resonance (NMR) technology, the study of itsmicrostructure is gradually widely used. New technology of magnetic resonanceimaging diffusion tensor imaging reflect the brain white matter fiber tracts in thedirection of the water molecules diffuse rely on features, post-processing observationcan produce a variety of images, such as VRAI, ADC and FA, the FA and ADC is one ofthe most important measure, FA images can display the structure of the brain whitematter fiber and anisotropic characteristics, MRI imaging voxel ADC said the internalmolecular diffusion movement range per unit time, its value, the greater the watermolecular diffusion ability stronger, so as the corpus callosum, the quantitative researchof brain white matter fiber. Corpus callosum diffusion tensor imaging has been widelyused in early brain development, normal brain aging and brain lateralization of research,but the DTI is unable to provide white matter fiber is how to connect betweenneighboring voxel. Along with the continuous development and the use of computersoftware, people using DTI data received by the brain white matter fiber imaging,known as diffusion tensor imaging of the bundle, DTT is a further development of DTItechnology, it can identify the brains of special fiber channel and the connectionbetween each other. Because of DTT is new application of magnetic resonance imagingtechnology, its name is unified, such as have called fiber tracking technology or white matter fiber tracts imaging, etc.Neuroimaging methods in recent years, including the resting state functionalconnectivity magnetic resonance imaging (MRI) and diffusion tensor imaging has beenused to assess brain function and structure of the network connection, compared withthe past has a more comprehensive evaluation about the distribution of the nervoussystem. Brain function and structure of gender differences research is a hot spot incurrent research. This study based on corpus callosum hofer DTI partition first,measurement of40cases of normal adult corpus callosum and subregion area and thecorrelation between age and gender differences， By diffusion tensor imagingmeasurement of40cases the40cases of normal adult corpus callosum knee andpressure of ADC and FA values, analyze the gender and age differences, providereference for further research. Finally through the example of the corpus callosum linefiber bundle imaging of normal adult, intuitive display of the corpus callosum fiberconnection, in vivo of anatomy teaching, scientific research and stereotactic surgery,interventional radiotherapy provides visual model, has a certain clinical value.Part1Gender differences Study in the normal adult of the corpuscallosum area and its subregionObjective: To explore the correlation between age and size of normal adult corpuscallosum and the Asia region, and gender differences in the corpus callosum area andsub-area.Methods: The median sagittal images40cases JEPG format import Photoshop CC, usethe "Magnetic Lasso" and "slice tool" division of the corpus callosum sub-regions in themiddle sagittal image, and then use the "magnetic lasso" tool will automaticallymeasured each sub-region pixel value, after conversion to get the area mm2.Results: Men corpus callosum total area and sub-area are larger than females, nostatistically significant difference between the two genders; to the median sagittaltelencephalon area of covariates on gender corpus callosum and sub-area covarianceanalysis showed that men and women of the corpus callosum total area and an area, thearea difference four districts were statistically significant; Men corpus callosum fourarea with age was significantly negatively correlated (P <0.01), and the R2value of itslinear regression (0.309) maximum, male corpus callosum total area, and a District,Second District, Third District,five area and age no correlation;female corpus callosum in four districts and age was negatively correlated (P <0.05), and the R2value of itslinear regression (0.247) maximum female corpus callosum total area and an area, theSecond District, Third District, five area and age no correlation; women overallcorpus callosum an area with age lines and curves negative correlation (P <0.05), fourarea with age was a significant linear curve negatively correlated (P <0.01), and the fourdistricts R2value of the area and the age-related linear regression (0.265) and curvefitting R2value (0.265) maximum overall corpus callosum total area and the secondarea, three districts and five area with age no correlation.Conclusion: Through the corpus callosum and sub-area of age-related timing changesand gender differences between men and women, and found that atrophy may existnormal adult corpus callosum area and sub-area increased with age selectively provide areference for the corpus morphology and neuropsychological studies callosum.Part2The Genu and Splenium of Corpus Callosum Diffusion TensorImaging Research in Normal AdultsObjective: To explore the genu and splenium of corpus callosum in normal adultdiffusion tensor imaging index change rule and gender differences.Methods: So that the center of the40cases of normal adults sagittal DTI images intoFUNCTOOL software, measuring the median sagittal and corpus callosum kneepressure of FA value, ADC values.Result: The genu and splenium of corpus callosum FA values and ADC values indifferent gender, no statistically significant difference.The genu of corpus callosum FAvalue difference was statistically significant in different age groups, the splenium ofcorpus callosum FA value difference was not statistically significant in different agegroups; the genu and splenium of corpus callosum ADC value difference wasstatistically significant in different age groups. The genu and splenium of corpuscallosum FA value were negatively correlated with age in normal adult. The genu andsplenium of corpus callosum ADC value were positively correlated with age in normaladult.Conclusion: The genu and splenium of corpus callosum FA value were negativelycorrelated with age,show that Along white matter increase myelination with the agegrowth. The genu and splenium of corpus callosum ADC value were positivelycorrelated with age, show that the more water molecules diffuse movement along with the age growth. This research of the genu and splenium of corpus callosum from part ofanisotropic and apparent diffusion coefficient to analyze the differences betweendifferent gender and age, provide a reference for further reflect the brain tissuemicrostructure and integrity.Part3Magnetic Resonance Diffusion tensor fiber bundles of corpuscallosum imagingObjective: To through the computer post-processing track the three-dimensional imageof fiber bundle of corpus callosum.Methods: Select1case of adult volunteers (the informed consent), right-handed, male,27years old. No neurological and psychiatric clinical outpatient medical system diseaseand family history, magnetic resonance imaging and conventional not seen obviousabnormity. Application of single excitation customize echo sequence line sagittal planeDTI scan. Head the median sagittal position DTI scan data automatically into HPxw8400Workstation, click FUNCTOOL diffusion tensor image post-processing into theinterface. By EPI distortion correction, manually select FA figure anatomy of the corpuscallosum area, click SetSeedROI, then click on the Tracking, the Tracking corpuscallosum white matter fiber tracts in the whole of the brain, according to get directioncode color figure, with transverse and coronal, sagittal view for reference.Results: Through post-processing workstation software line DTT track of fiber bundles,clearly show the shape and structure of the corpus callosum. Around because of thecorpus callosum mainly contain contorts the fiber bundle, the color coding part of theanisotropy on the drawing in red, are easy to identify, especially in the middle of sagittalplane is the most clear, slightly assumes the half moon shape. And by changing thedifferent direction to see images of the corpus callosum fiber bundles track, from the top,bottom, left side, right side, front, back to display.Conclusion: DTT despite the data acquisition, data processing, and other factors, but asa rapid development of technology, has a broad prospect of clinical application.Through the study of a large number of brain white matter fiber tracts, the brain whitematter fiber tracts mapping, thus more conducive to lesion location, better for nervesurgery and interventional radiotherapy planning provides the certain application value,but also provide standards for anatomy teaching living visual model. |
PDF Full Text Request