Study On Diffusion Tensor Imaging In Evaluation Of Normal Truncus Corporis Callosi Development And Fiber Tracts

Objective To evaluate the value of Diffusion TensorImaging in the development of normal truncus corporis callosi.MethodsCollected cerebral diffusion tensor imaging data of241people withoutabnormal central nervous system signs or symptoms and anomalous signalsin conventional MRI through the Siemens3.0T MRI. According to their ages,divided into10groups: Group1(≤1year old, M11, F10), Group2(1～3year old, M10, F10), Group3(3～6year old, M12, F13), Group4(6～12year old, M12, F13),Group5(12～18year old, M14, F10),Group6(18～30year old, M12, F13), Group7(30～40year old, M11, F14), Group8(40～50year old, M13, F13), Group9(50～60year old, M12, F13)and Group10(60～80year old, M12, F13). Diffusion Toolkitpost-processing software tool was used to measure the FA value and ADCvalue in the same ROI(regions of interest) of four regions of truncuscorporis callosi. The difference of every region different age groupsbetween sexes was analyzed with Independent-Sample T Test; Recorded theFA value and ADC value of every group, and drew the line chart; Thedifference of every area among different age groups was analyzed withOne-Way ANOVA, followed adjacent groups comparing. FA value, ADC valueof every subregion was respectively paired with age, for Spearman rankcorrelation analysis. Results There was no statistical significance inFA or ADC value of every truncus corporis callosi subregion between genders（P＞0.05）;There had a statistically significant in FA or ADCvalue of every subregion among different age groups（P＜0.05）,and haddiverse results between adjacent groups; Before18years old, there wasa positive correlation between age and FA value of every truncus corporiscallosi subregion, while the ADC value is opposite; After18yearsold,there had a negative correlation between age and FA value of everytruncus corporis callosi subregion, while there had no correlationbetween age and ADC value. Conclusions Diffusion Tensor Imaging couldreflect the microstructural change of the development of normal truncuscorporis callosi. The FA and ADC value of different regions of normaltruncus corporis callosi have a certain rule. Objective To evaluate the value of Diffusion TensorImaging in fiber bundles’ length, density and trajectory of every normaltruncus corporis callosi subregion. Methods Collected cerebraldiffusion tensor imaging data of241people without abnormal centralnervous system signs or symptoms and anomalous signals in conventionalMRI through the Siemens3.0T MRI. According to their ages, divided into10groups: Group1(≤1year old, M11, F10), Group2(1～3year old, M10, F10), Group3(3～6year old, M12, F13), Group4(6～12year old,M12, F13),Group5(12～18year old, M14, F10),Group6(18～30year old,M12, F13), Group7(30～40year old, M11, F14), Group8(40～50yearold, M13, F13), Group9(50～60year old, M12, F13) and Group10(60～80year old, M12, F13). TrackVis post-processing software tool was usedto process four subregions of truncus corporis callosi. Calculated and recorded fiber bundles’ length and density of four subregions, and drewthe line chart; The difference of every region different age groupsbetween genders was analyzed with Independent-Sample T Test; Thedifference of every area among different age groups was analyzed withOne-Way ANOVA, followed adjacent groups comparing. Length, Density ofevery subregion was respectively paired with age, for Spearman rankcorrelation analysis; Length, Density of every subregion was respectivelypaired with FA value, also for Spearman rank correlation analysis; Observed young people fiber bundles’trajectory of each subregion usingfiber fusion technology. Recorded fourth subregion fiberbundles’terminal positions of different age groups, for R×C Chi-squareTest， followed adjacent groups comparing. Results There was nostatistical significance in Length or Density of every truncus corporiscallosi subregion between genders（P＞0.05）;There had a statisticallysignificant in Length or Density of every subregion among different agegroups（P＜0.05）,and had unlike results between adjacent groups; Before18years old, there was a positive correlation between age and Length ofevery truncus corporis callosi subregion, and also between age and Density;After18years old, there had a negative correlation between age and FAvalue of every truncus corporis callosi subregion, and also between ageand density. There was a positive correlation between FA value and Lengthof every truncus corporis callosi subregion, and also between FA valueand Density. No statistical significance was found in fourth subregionfiber bundles’terminal positions of different age groups（P＞0.05）,andalso between adjacent groups（P＞0.05）. Conclusions Diffusion TensorImaging can reflect the change of fiber bundles and the trend of fiberbundles’ trajectory of normal truncus corporis callosi.