Effects Of ω-3Fatty Acids During The Operation Inflammatory Reaction In Gastric Carcinoma Patients With Nutritional Risk

Objective: To investigate omega-3polyunsaturated fatty acids on the impactof the release of inflammatory cytokines in patients with gastric carcinoma inoperation. Evaluating investigate omega-3polyunsaturated fatty acids on theinfluence of macrophages with intraperitoneal in patients with gastriccarcinoma in operation.Assessing omega-3polyunsaturated fatty acids on theaffection of cell infiltration with peritonitis in patients with gastric carcinoma inoperation.Assessment of omega-3polyunsaturated fatty acids in inflammatoryresponse in patients with gastric cancer.Methods: Choose the objects of study from the gastric carcinoma patientscoming to our hospital during2013-06and2014-01.The included forty-sevenpatients were randomly divided into two groups (single-blind study):controlgroup (n=26)and trail group (n=21).From the three days before operation to thefifth day after operation, in addition to the routine nutritional support treatment,the trail group also received ω-3PUFA0.2g/kg/d.1.Determination of thenumber of macrophages in abdominal cavity lavage；2. Determination of TNFalpha in abdominal cavity lavageTNF-α, IL-1, lL-6, lL-10；3. Assessmentcellinfiltration with peritonitis;4.Compare the situation on the third day after fullabdominal CT. Results:1、Trail group patients have lower level of the number of macrophageswith intraperitoneal than the control group iwith gastric carcinoma in operation.2、Compared with the control group，Trail group were dcreased on therelease of inflammatory cytokines in operation。3、Cell infiltration with peritonitis were reduced in the Trail groupcompared with the control group.4、Omega-3PUFAs can reduce fatty clearance intraperitoneal postoperativeinflammatory reaction in the abdominal cavity on reduce postoperative.Conclusions:The preoperative application of ω-3polyunsaturated fatty acids inperioperative may reduce the activation of macrophages with intraperitoneal fornutritional risk in patients with gastric cancer, inhibit the release ofinflammatory cytokines, reduce cell infiltration with peritonitis the degree ofreaction abdominal inflammation in operation, regulate cellular and humoralimmunity.