Research And Development Of Anti-fatigue Health Wine With Radix Pseudostellariae

Fatigue is an important issue that can not be ignored in the fast-paced modern life, this subject intend to Radix Pseudostellariae as the main material, developed to alleviate physical fatigue health wine.Radix Pseudostellariae is commonly used in.traditional chinese medicine from the Chinese Pharmacopoeia2010edition, with functions of Yi qi jian pi and Sheng jin run fei, spleen clinically used for body tired and other symptom, and with the function similar as ginseng, but known as light not characterized by lifting Qi, and produce Jin not to help wet, set upright or straight not keep perverse trend, tonic but not violent.According to the traditional Chinese medicine regimen and health care theory and the theory of modern medicine, literature and comprehensive pharmacology studies, selected Astragalus, Heterophylla, Epimedium, Wolfberry fruit and Jujube from Chinese medicine, with functions of nourishing Gan and Shen, to supplement blood and soothe the spirit in the prescription.Based on the formulations and dosage formulations, the total saponins and polysaccharides orthogonal test method are chosen as the index components, using single factor testing, screening prescription medicine optimum extraction. Astragalus and Radix Pseudostellariae upcoming crushed to10mesh, Epimedium broken off after the10mesh sieve, jujube to go nuclear, medlar smashed, at room temperature, add herbs five times the amount of50%vol amount of liquor soaked seals, each stirred for2days, every30min, stirring for every1week after1week, total immersion for25d. Hook modulation to obtain the product alcohol to be30%vol, sugar content is60g/L.Wine samples of Radix Pseudostellariae prepared to use to relieve physical fatigue function experiments, low dose group, middle dose group and high dose group and the base liquor control group and negative control group, the mouse weight loading swimming experiment and blood lactic acid test, hepatic glycogen and blood urea nitrogen experiment^As a result, Low-dose group (8.35mL/kg.d), middle dose group (16.7mL/kg.d) mice swimming time was significantly longer than the control group (P<0.01); in the Low-dose group and middle dose group, areas under blood lactate curve compare with the control group, the difference was statistically significant (P<0.05, P<0.01); glycogen cost relatively in low dose group and middle dose group of mice with the negative control group and the movement of wine base control group, the difference was significant(P<0.01); urea nitrogen experiment in low does and middle dose group and negative control group by BUN values and wine base control group, the difference was statistically significant(P<0.05). What means, by the swimming test and three biochemical markers experimental results may be initially determined that the test sample has alleviate physical fatigue function. By liver biopsy staining base liquor and drugs on the liver tissue was hurt or not, that there is no significant pathological changes in liver tissues.In this paper, based on theoretical knowledge of various multi-disciplinary, we initially developed to alleviate physical fatigue health wine recipe efficacy and functions, which provides references for the applications of health wine.