Kidney Phlegm And Activating Blood Method In The Treatment Of Mild Cognitive Impairment After Stroke Of Clinical Study

Objective: Based on the principle of dialectical treatment of traditionalChinese medicine, this study treated twenty patients with mild cognitiveimpairment after stroke by the method of benefiting kidney invigorate thecirculation of phlegm and observed the change of cognitive function and dailylife ability of3months and6months after the stroke patients which with mildcognitive impairment in order to investigate kidney invigorate the circulationof phlegm method clinical curative effect for the treatment of mild cognitiveimpairment after stroke.Method: In October2012to October2013in hebei province hospitalclinic patients,20people into the group selection into the standard,wererandomly divided into treatment group and control group (n=10), randomizedcode generated by SAS statistical software package. Two groups on the basisof health education and health promotion, treatment group with FufangCongrong Yizhi Jiaonang,4/time,3times per day,6months continuousadministration; The control group is not medication. To get a medicinetreatment group every2weeks, so that the presence of drug adverse reactionswere observed. By unified trained personnel, respectively, prior to the drugpreparation after3months and6months after the investigation, fill out relatedforms, including the Mini Mental State Examination Scale (MMSE), Montrealcognitive assessment Beijing edition (MoCA) and clinical dementia ratingscale (CDR), and compared with control group, to assess the curative effect.Results:1General informationThis study patients a total of20people, average age64.1±5.9years,15men (75%),5women (25%), each10people were randomly divided intotreatment group and control group, after statistics analysis, two groups of patient’s age, gender, educational level, history of alcohol, tobacco, andcommon merger case there was no significant difference (P>0.05).2Change of the integral analysis of scaleMMSE score analysis: Comparison in the group: in the control group,MMSE was27.60±0.70points before treatment, after3months of27.50±0.53points, after6months was27.10±0.88, after a paired t test, use3monthsbefore the treatment without difference, and six months, although statisticallysignificant but levels are falling before treatment; in the treatment group,MMSE was27.60±1.17points before treatment, medication after3months of27.70±1.25points, after six months of27.70±1.42points, are all P>0.05,no statistical difference. Comparison between groups: with group t test,3months and6months after all is P>0.05, no statistical difference.MoCA integral analysis: Comparison in the group: in the control group,MoCA was23.70±1.77points before treatment, medication after3months of24.50±1.35points, the paired t test, P>0.05, no statistical difference, after6months was24.80±1.81, P <0.05, the score from the previous increase, maybe associated with health education and health promotion; in the treatmentgroup, MoCA was24.20±1.03points before treatment, after3months of26.10±1.85points, after six months of25.80±1.69points, was statisticallysignificant, the score from the previous, the patient MoCA score was improved.Comparison between groups: with group t test, after3months and6monthsafter the score of two group were statistically significant, P <0.05, score intreatment group were higher than the control group. Application shows thatkidney phlegm and blood-activation therapy after stroke patients with mildcognitive impairment, cognitive function in patients is improved.ADL integral analysis: Comparison in the group: in the control group, theADL before treatment was21.10±1.73points, medication after3months of21.10±1.67points, after6months was21.10±1.73points, the paired t test, P>0.05, had no statistical difference; in the treatment group, the ADL beforetreatment was21.90±3.78points, medication after3months of21.60±1.84points, after6months was21.30±1.77points, the paired t test, P>0.05, no statistical difference. Comparison between groups: using group t test,medication after3months score no statistical difference in both groups, drugscore6months after two groups had no difference, P>0.05.3The judgement of clinical curative effectLook after3months using MoCA curative effect indexes, including thecontrol0cases were markedly effective, effective in2cases (20%),7cases(70%), deterioration in1case (10%). Treatment group1case (10%) weremarkedly effective, effective in1case (10%),7cases (70%), deterioration in1case (10%). Via wilcoxon rank two samples and test, P>0.05, there was nosignificant difference in both groups, both group total effective rate was20%.Look after6months using MoCA curative effect indexes, including thecontrol0cases were markedly effective, effective in1cases (10%),8cases(80%), deterioration in1case (10%). Treatment group0case were markedlyeffective, effective in3case (30%),6cases (60%), deterioration in1case(10%). P <0.05, there are differences between the two groups of curativeeffect, the curative effect of treatment group (the total effective rate30%) isbetter than that of control group (total effective rate10%).Conclusion: treatment group in improving patients’ cognitive function isbetter than that in control group, this study confirmed that the application ofkidney phlegm qi and the curative effect of treatment of mild cognitiveimpairment after stroke is exactly safe, should further carry out large sampleresearch to promote the clinical application.