Immunochemical Detecting And Clinical Controlled Analysis Of Clusters And Sporadic Cases Of Guillain-barre Syndrome In The Regional Of Changchun

Background and Objectives:Guillain-Barré Syndrome(GBS) happens all over theworld,the clusters of GBS occur rarely.The clusters of GBS between June and July of2007inShuangyang district of Changchun City had attracted the attention of scholars. At presentmost of scholars believe that anti-ganglioside antibodies are associated with the pathogenesisof GBS, detecting the corresponding anti-ganglioside antibody level in patients of GBS hasimportant significance,but until now we do not know whether there have a difference ofanti-ganglioside antibody level between clusters and sporadic cases of GBS. This papercompares the difference of GM1and GT1a antibody level between clusters and sporadic casesof GBS and analysis the relationship of antibody level and clinical symptoms.Methods:We both select parts of GBS patients in shuangyang district and sporadic casesbetween Apr,2012to Jan of2013,all the patients were hospitalized in the neurologydepartment of first hospital of Jilin University. We also randomly select some patients withheadache from the neurology outpatient and department as healthy group. ELISA method isapplied to detect three groups of GM1and GT1a antibody level and at the same time analysisclinical features of clusters and sporadic cases of GBS.Results:(1) The incidence of two groups is men more than women; The onset age is20～40years old; the main symptom is limb weakness.Cranial nerve damage appeardiplopia, facial paralysis, and difficulty in swallowing; electrophysiological performance ismainly axonal injury.(2) The infections of digestive（P=0.008)and respiratory（P=0.026）havestatistically significance between clusters and sporadic cases of GBS.The main infection ofthe clusters is digestive tract while the sporadic cases is respiratory tract infection.(3) GM1and GT1a antibody level of the clusters and sporadic cases of GBS in serum andcerebrospinal fluid have no significant differences (P＜0.01), but the antibody levels of GBSare significantly higher than healthy control(P＞0.05).(4) GT1a antibody level with bulbarparalysis is higher than those without bulbar paralysis(P＜0.05).(5)GM1antibody level isassociated with the electrophysiological change, antibody level of demyelinating and axondamage patients is the highest, followed by pure axonal injury and demyelinating injure is thelowest level.(6) The heavier illness has higher GM1and GT1a antibody levels in serum andcerebrospinal fluid,but there are no statistical differences(P＞0.05). Conclusions:(1) The main infection of clusters of GBS is digestive tract while thesporadic cases is respiratory tract.(2)GM1and GT1a antibody levels of the clusters andsporadic cases of GBS are significantly higher than healthy control,but the antibody levels oftwo groups have no difference, suggesting GM1and GT1a antibody are involved in thepathogenesis of GBS process.(3)GT1a antibody may play an important role in GBS withbulbar paralysis.(4) GM1antibody level may associated with the electrophysiological change,hoping enlarge sample size to further validation.