| Objective: To investigate the expression of Lgr5and CD44in gastric cancer tissueand correlations with clinicopathological factors and prognosis.Methods: A retrospective analysis was made of273cases of patients who hadundergone gastrectomy from2005to2008for gastric adenocarcinoma. Tissue microarrayand immunohistochemical staining was employed to detect the expression of Lgr5andCD44to analyze their relationship with the clinicopathological factors and prognosis ofgastric adenocarcinoma.Results: Lgr5expression was associated with advanced pathological TNMstage(P=0.025). Lgr5expression was not associated with poorly differentiated histology,invasion depth, lymph node metastasis and lymphatic invasion(P＞0.05). CD44expression was not correlated with clinicopathological features(P＞0.05). Lgr5expression was not correlated with CD44expression（p=0.8605）. High Lgr5expression，high CD44expression，poorly differentiated histology and advanced pathological TNMstage were strong predictors of death in logistic regression analysis. Both Lgr5expressionand CD44expression were associated significantly with poor overall survival in univariateanalysis(P<0.05). Furthermore, in multivariate analysis, Lgr5and CD44were independentmarkers of poor prognosis, along with pathological TNM stage and histologic grade(P<0.05).Conclusions: Tissue microarry was an effective high-throughput technique for thestudy of tumor molecular pathology. Lgr5expression and CD44expression might beuseful markers of poor prognosis in gastric cancer. |
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