The Value Of Cerebrospinal Fluid Aβ And Tau In Diagnosis Of Mild Cognitiveimpairment Due To Alzheimer’s Disease

Objective：To explore the value of cerebrospinal fluid Aβ and tau indiagnosis of mild cognitive impairment due to Alzheimer’s disease.Methods：All subjects were recruited from neurology ward andclinic, first affiliated hospital of Guangxi medical university fromDecember2012to October2013.The cerebrospinal fluid Aβ42, T-tau andP-tau protein were determined using Enzyme-linked immunosorbentassay in52mild cognitive impairment patients due to AD and36normalmental state group. Statistical analysis was performed using SPSS16.0.Results: The cerebrospinal fluid Aβ42content of the two groupswere644.26±158.49、921.55±171.28pg/ml（P<0.05）. The cerebrospinalfluid T-tau content of the two groups were645.86±162.47,432.82±123.25pg/ml（P<0.05）. The cerebrospinal fluid P-tau content ofthe two groups were513.13±150.02、321.90±105.06pg/ml（P<0.05）.Using ROC curves: The accuracy of cerebrospinal fluid Aβ42is88.0%，the sensitivity was81.5%and the specificity is79.6%. The accuracy ofcerebrospinal fluid T-tau is82.3%，the sensitivity is79.8%and the specificity was76.5%. The accuracy of cerebrospinal fluid P-tau is86.7%，the sensitivity was81.6%and the specificity is79.4%. Theaccuracy of cerebrospinal fluid T-tau+P-tau is88.6%，the sensitivity was83.4%and the specificity is82.7%. The accuracy of cerebrospinal fluidT-tau+Aβ42is90.8%，the sensitivity was88.3%and the specificity is86.9%. The accuracy of cerebrospinal fluid P-tau+Aβ42is92.3%，thesensitivity was90.7%and the specificity is88.7%. The accuracy ofcerebrospinal fluid T-tau+P-tau+Aβ42is97.8%，the sensitivity was95.7%and the specificity is93.5%.Conclusion:1.The cerebrospinal fluid Aβ and Tau protein in MCIpatients were higher than those in healthy controls.2.Compared withsingle test, combined tests have higher accuracy for diagnosing MCI.