| With the development of economic and society, population age structure has changed a lot. Aging people increases year by year, together with the various diseases associated with age. Alzheimer’s disease (AD) is the most common form of dementia. It is a degenerative disease of thenervous system and can’t be treated. As it progresses, patients with AD have nothing to do but waiting the coming of death. For the reasons above, this disease brings enormous pressure to the patients and their families. Mild cognitive impairment (MCI) is regarded as a transitional state between normal aging and dementia, especially Alzheimer’s disease. MCI is defined by deficiencies in memory that do not significantly impact daily functioning. If early prediction and intervention can be done on the patients with MCI, the condition probably can be controlled.Along with the development of medical imaging technology, more and more methods are applied in the brain research. The functional magnetic resonance imaging (fMRI), for its inherent advantages, notably safety and high spatial-temporal resolution, becomes the most popular neuroimaging procedure and is widely used to investigate the functional abnormal in human brain. In this study, we used resting state functional magnetic resonance imaging to detect the whole brain fractional amplitude of low-frequency fluctuations (fALFF), functional connectivity andfunctional network in32amnestic MCI subjects and28healthy elderly normal controls.In this study, we explored the functional network of MCI patients using the fMRI for the first time. In order to describe the network properties, clustering coefficient and global efficiency were calculated. Besides, most of previous studies on MCI investigated the abnormal changes in brain from one certain aspect, but in our research, we combined with these three methods--fALFF, functional connectivity and functional network to study the dysfunctional activity of the brain. This multi-aspects method can be more efficient and comprehensive to understand the pathophysiological mechanism of mild cognitive impairment. |
