Influences Of Erythropoietin On Glucose Tolerance Of Rats With5-fluorouracil

1.ObjectiveTo investigate the influences of erythropoietin (EPO) on blood glucose and insulin secretion of5-fluorouracil(FU) treated rats.2.MethodsWistar rats (n=40) were randomly allotted into4groups (5-fluorouracil plus normal saline group (FU+NS);5-fluorouracil plus erythropoietin group (FU+EPO); erythropoietin plus normal saline group (EPO+NS); normal saline control group (NS)). The function was evaluated by oral glucose tolerance test (OGTT), level of blood glucose, and insulin secretion.3.ResultsDuring OGTT, the level of blood glucose of0min,30min,60min,120min were higher than NS group (F=38.1～58.2, q=4.17～4.33,P<0.05);Insulin releasing test:at OGTT30min,60min, the peak secretion time of plasma insulin was lower than the NS group (F=16.3、29.9, q=4.33、4.64,P<0.05),P<0.05); For OGTT Omin,30min,60min,120min, EPO+FU group showed blood glucose were lower than FU+NS group (q=3.96～4.11,P<0.05); Insulin releasing test:at OGTT60min, the insulin level of EPO+FU group was higher than FU+NS group (F=29.9,q=4.61, P<0.05).4.ConclusionFU-induced hyperglycemia appears to be mediated partly by a relatively deficient insulin secretion to glucose stimulation. By regulating insulin secretion, EPO can partly improve FU’s impact on the body glucose metabolism.