The Change And Diagnostic Value Of Procalcitonin,C-reactive Protein And WBC In Blood In Chronic Hepatitis B Cirrhosis Patients With Spontaneous Bacterial Eritonitis

Objective:To observe the change of procalcitonin (PCT),C-reactive protein (CRP) and WBC in chronic hepatitis B cirrhosis patients with spontaneous bacterial peritonitis (SBP),and to analyse their diagnostic value for SBP.Methods:50patients with CHB cirrhosis with SBP(the group with SBP)and50cases of CHB cirrhosis without SBP(the group without SBP)were collected.The content of procalcitonin in blood of all100patients were measured,White blood cells, c-reactive protein as well.Then to draw the receiver operating characteristic(ROC)curve,and record the area under the curve(AUC),95%confidence interval(95%CI)and the cut-off values of specific diagnostic sensitivity and specificity.Results:(1)There were differences in the content of WBC,CRP and PCT in chronic hepatitis B cirrhosis patients with spontaneous bacterial peritonitis(SBP)and without SBP(SBP).In the group with SBP,the level of procalcitonin, C-reactive protein and WBC was0.599±0.196ng/mL,22.470±8.213mg/L and7.669±2.572×109/L respectively, while in the group without SBP, the level of PCT, CRP and WBC was0.291±0.121ng/mL,8.976±5.504mg/L and4.494±1.859x109/L. PCT, CRP and WBC concentrations in blood were significantly higher in the group with SBP than the group without SBP(P<0.05).(2) The area under the curve(AUC),95%confidence interval (95%CI) and the cut-off value of90%specific diagnostic sensitivity and86%specificity of PCT was respectively0.9260.875-0.977,0.415mg/L, while AUC,95%CI and70%specific diagnostic sensitivity and90%specificity of CRP was0.911,0.858-0.964and17.15mg/L. The corresponding result of WBC was AUC,0.852;95%CI,0.779-0.925;66%specific diagnostic sensitivity and80%specificity,6.27×109/L. The AUC of PCT and CRP were much larger than the WBC(P<0.05).The optimal cut-off value of PCT was0.415ng/ml,WBC was17.15mg/L.And the relevant inspection showed that there was a linear positive correlation between the PCT and CRP,WBC,the r value was0.743and0.743.Conclusions:WBC,CRP and PCT concentrations in blood were significantly higher in the CHB cirrhosis with SBP patients, but the CRP and PCT have higher diagnostic value for SBP.