| Objective:To investigate the effects of ivabradine (Iva) on IL-10and IL-17expression in myocardial cells of rabbit after myocardial infarction (MI) and its role in improving ventricular remodelin.Methods:A total of46New Zealand white rabbits were used to build myocardial infarction model through ligating left anterior descending coronary artery. The successfully prepared36rabbis were randomly divided into4groups,9rabbits for each group:sham operation group (S group, thoracotomy without ligation), myocardial infarction group (MI group), bisoprolol treatment group (B group) and ivabradine treatment group (Iva group). Drugs were given12hours post myocardial infarction induction, rabbits in B group and Iva group were given bisoprolol1.25mg/d and ivabradine17mg/kg/d respectively for4weeks; rabbits in S group and MI group were given same dose of saline at the same time for four weeks. After four weeks, Body mass, left and ventricular mass were weighed, and IL-10and IL-17expression in myocardial cell was detected by immunohistochemistry method.Results:Four weeks after operation, the relative ventricular mass of rabbits in MI group was increased compared with S group (P<0.01); compared with MI group, the relative ventricular mass of rabbits in B group and Iva group was decreased (P<0.05). Compared with MI group, IL-10expression in B group and Iva group was significantly up-regulated (P<0.01) and IL-17expression was significantly down-regulated (P<0.01), and the difference was significant (P<0.01). Compared with S group, no significant difference was found for B group and Iva group.Conclusions:After four weeks treatment, Iva could improve ventricular remodeling through increasing the expression of myocardial anti-inflammatory cytokine IL-10and decreasing the expression of proinflammatory cytokine IL-17, and it has some effects in protecting myocardial cells. |
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