| Objectives: The goals of this document are to investigate thecorrelation between ankle-brachial index and urinary microalbumincreatinine ratio（ACR）in type2diabetic mellitus（T2DM）patients,providing a new basis for the prevention and treatment of clinicaldiabetic nephropathy.Methods: All the310patients were divided into2groupsaccording to ABI, where75of them were for T2DM with peripheralarterial disease (ABI <0.9), and235of them were for T2DM withoutperipheral arterial disease (ABI≥0.9). Then the patients withperipheral arterial disease were divided into mild decline ABI groupand moderate decline ABI group based on the differences of urinarymicroalbumin creatinine ratio (ACR). After that, differences of ACRbetween the two groups were compared，and the correlation betweenABI and urinary ACR were analyzed.Results: The ratio of abnormal ACR in group of T2DM withperipheral arterial disease were significantly higher than that ofT2DM without peripheral arterial disease, which were68.00%and6.38%respectively. The differences between the two groups were statistically significant(P<0.05), and the differences in age,duration, systolic blood pressure, diastolic blood pressure, bodymass index, total cholesterol, high-density lipoprotein cholesterol,low-density lipoprotein cholesterol, triglyceride levels, whiteblood cell count and hemoglobin were not statistically significant(P>0.05). The patients’ ACR of the ABI moderate decline group weresignificantly higher than that of slightly decreased group, whichwere84.00%and60%respectively, and the differences between thetwo groups were statistically significant(P<0.05). The ABI wasnegatively correlated to ACR（r=-0.412，P<0.01）.Conclusions: The rate of abnormal ACR in T2DM with peripheralarterial disease group was significantly higher than that withoutperipheral arterial disease group,correlation analysis showed thatthere was a significant correlation between ABI and ACR, whichindicated that ABI may be an independent risk factor for diabeticnephropathy. |
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