Erythroderma:a Clinical Analysis Of98Cases And Literatures Review

[Objective]:To detect the etiologys and inducements of the erythroderma, its clinical manifestations, the laboratory findings, the treatments and its effects.[Methods] This study collected Clinical data of98cases with erythroderma patients in the Qilu Hospital of shandong university from2006.12to2012.12. Various clinical parameters were analyzed using SPSS19.0statistical software,such as general condition, causes, inducement, clinical manifestations, laboratory and other auxiliary examination,the influencing factors of clinical treatment effect.[Results]1) General condition74of98cases in erythroderma patients were males,the females were24cases,the ratio between male and female is3.08:1. Aged at8～86years old, and the average age is52.60±21.33.2) Type61of98cases are occurring secondary to a preexisting skin condition(63.27%;43of61cases are psoriasis,12cases are eczema,2cases are hypereosinophilic dermatitis,1case is contact dermatitis,1case is solar dermatitis,1case is senile pruritus,1case is atopic dermatitis),23of98cases are drug allergy (23.47%),2of98cases are malignancy(2.04%),l of98cases is metabolic arthritis(1.02%),11of98cases is unknown cause(11.22%).3) Clinical manifestations96of98cases are pruritus.53of98cases are f ever(37.3-40℃).10of98cases are tachycardia.Almost all of the patients are found varying degrees oferythema,desquamation,scales,infiltration and turgidity involving greater than90%of the skin surface.42of98cas es are involved scalp and hair.23of98cases are involvedRefers to the nail s.13of98cases are exudation.4of98cases are involved eye conjunctiva.4) Laboratory tests The white blood cell total elevates40examples (40.8%),Eosno phils ercentage elevates28examples (28.6%), Blood sedimentation elevates25examples (25/57).Liver function is abnormal26cases.Plasma albumin decl ines71examples. Electrolyte disorder in10cases. Squmaous Cell Carcinoma Antigen elevates16examples (16/33), Lactic Dehydrogenase elevates54exa mples (54/97,55.7%)26cases with abnormal ECG.5) Treatment and curative effect All patients applicated with glycyrrhiza preparations and kushenin.34of98cases are glucocorticoid treatment.29of98cases are antibiotic treatment.16of98cases are immunosuppressive therapy.16of98cases are glucocorticoid treatment combined with immune inhibitors.9of98cases are Vitamin A acid drugs treatment.Effects:Effective rate is80.61%.27of98cases are recovery(27.55%).52of98cases are effective in treatment(53.06%).16of98cases take a turn for the better(26.33%).2of98cases are ineffectiveness(2.04%).l of98cases are died(1.02%).Erythroderma patients has a long hospital stay.Average in hospital days is17.02±9.72days.10of98cases are many admitted to hospital.[Conclusions]1) Erythroderma may happen at any age,mostly occurring in middle-aged and old male patients, the ratio between male and female is3.08:1.2) Erythroderma is mainly secondary to the original skin diseases. The highest proportion of the primary disease psoriasis is63.27%; The next highest proportion of drug allergy is23.47%, mostly having clear medical history,the short duration, and good prognosis;11.22%proportion associated with unknown reasons; A few associated with malignant tumor, autoimmune diseases and metabolic diseases.3)The main inducement of erythroderma is unreasonable treatment,infection and local adverse stimulus.4) Erythroderma patients commonly merge systemic symptoms,such as fever, hypoalbuminemia, anemia, infection, liver injury.5)Erythroderma infection has nothing to do with the age.The infection rate of plasma albumin levels lower than normal plasma albumin levels is higher, and the statistical difference (p<0.05).However,other potential risk factors, such as abnormal liver enzymes, combined internal basic diseases, skin and mucous membrane has burst/seepage are the indicators of normal infection rate is higher,.but which have no statistical difference between group with the infection.6)Erythroderma is characterized by sudden occurrence,severeSymptoms, the prognosis of which depends on the cause, complications, and treatment. Strengthening the support therapy and skin care is an important premise of the illness recovery. Those conventional treatment invalid patients choose to use glucocorticoid separately or combined according to the etiology.