| Objective Retrospective analysis the different histological types of gastrointestinalpolyps in491cases of patients with polyps size, age, gender, location and othercharacteristics of clinical medicine and the patient, to observe the clinical features ofgastrointestinal polyps, polyps explore relevant laws.Methods A total of491patients with polyps in the Second Affiliated Hospital of AnhuiMedical University from September2009to October2012were studiedretrospectively，To analysis the different histological types of gastric polyps parts ofpolyps in the pathogenesis of Helicobacter pylori infection、use of proton pumpinhibitors and proton pump inhibitors in246cases of gastric polyps. To analysis the245cases colorectal polyps patients with endoscopic features, compare the size of colorectalpolyps, and the number and type of characteristics and follow-up of pathologicalsituations. Colon tissue and blood samples of normal mucosa, colorectal hyperplasticpolyps, adenoma and adenocarcinoma were obtained from105patients undergoingcolonoscopy. The expressions of SOD, MDA were examined by ELSA.5-LOX, VEGF,PLGF and NF-KB protein expression was quantified by immunohistochemistry. Theactivity of SOD in the plasma of adenocarcinoma was significant lower than that in theother groups. The expression levels of Sod’s activity revealed a grasual downward trend from the normal control to colorectal hyperplastic polyps, low-gradeintraepithelial neoplasia, high-grade intraepithelial neoplasia and adenocarcinomagroups respectively. We observed significant different between the colorectalhyperplastic polyps and high-grade intraepithelial neoplasia.Results The number of gastric polyps found in491cases of polyps was246, including87men and159women. Gastric polyps were most commonly seen in the antrum,followed by gastric and cardia. The number of hyperplastic gastric was131,76caseshad inflammatory polyps,37cases had adenomas polyps and2cases had fundic glandpolyps. Compared with hyperplastic polyps, inflammatory polyps and adenomatouspolyps were had no statistically difference. Compared with hyperplastic polyps,adenomatous polyps was had statistically significant difference. The HP infection ratesin inflammatory polyps, hyperplastic gastric polyps and adenomatous polyps was45.31%,31.11%and58.33%. There were95patients with gastric polyps PPI, including35.79%of inflammatory polyps,50.53%of hyperplastic polyps, adenomatous polypsaccounting for13.68percent and fundic gland polyps was1.05%, wherein anydifference between the two was not statistically significant. and the time of the PPI usedwas not statistically difference significant. There are245cases of colorectalpolyps,including172men and73women, and there were187cases of adenomatouspolyps,43hyperplastic polyps and39inflammatory polyps. Colorectal polyps weremost commonly seen in the sigmoid colon and rectum, followed by the descendingcolon, transverse colon, ascending colon and terminal ileum. There were20cases ofcolorectal polyps found in follow-up after resection, have two years of new polyps,polyps are sessile or Rebagliati,70%of adenomatous polyps. The activity of SOD inthe plasma of adenocarcinoma was significant lower than that in the other groups. The expression levels of SOD’s activity revealed a grasual downward trend from the normalcontrol to colorectal hyperplastic polyps, low-grade intraepithelial neoplasia, high-grade intraepithelial neoplasia and adenocarcinoma groups respectively. We observedsignificant different between the colorectal hyperplastic polyps and high-gradeintraepithelial neoplasiahe expression of MDA in the plasma of adenocarcinoma wassignificant higher than that in the other groups. The expression levels of MDA revealeda grasual upward trend from the normal control to colorectal hyperplastic polyps,low-grade intraepithelial neoplasia, high-grade intraepithelial neoplasia andadenocarcinoma groups respectively. We observed significant different between thehigh-grade intraepithelial neoplasia and low-grade intraepithelial neoplasia, low-gradeintraepithelial neoplasia and normal mucosa. When compared with normal mucosa,colorectal hyperplastic polyps, high-grade intraepithelial neoplasia and adenocarcinomapresented higher expression of5-LOX; the expression of5-LOX in adenocarcinomawas significantly higher than the group of low-grade intraepithelial neoplasia andcolorectal hyperplastic polyps. The expression levels of VEGF revealed a grasualupward trend from the normal control to colorectal hyperplastic polyps, low-gradeintraepithelial neoplasia, high-grade intraepithelial neoplasia and adenocarcinomagroups respectively. When compared with high-grade intraepithelial neoplasia,low-grade intraepithelial neoplasia and colorectal hyperplastic polyps, normal mucosapresented lower expression of VEGF; the expression of VEGF in high-gradeintraepithelial neoplasia was significantly higher low-grade intraepithelial neoplasia.When compared with adenocarcinoma, low-grade intraepithelial neoplasia, andcolorectal hyperplastic polyps, normal mucosa presented lower expression of PLGF. Intissue of high-grade intraepithelial neoplasia the expression of PLGF was significanthigher than colorectal hyperplastic polyps. The levels of PLGF revealed a grasual upward trend from the normal control to colorectal hyperplastic polyps, low-gradeintraepithelial neoplasia, high-grade intraepithelial neoplasia and adenocarcinomagroups respectively. When compared with normal mucosa, colorectal hyperplasticpolyps, low-grade intraepithelial neoplasia, high-grade intraepithelial neoplasia andadenocarcinoma presented higher expression of NF-KB. In tissue of colorectalhyperplastic polyps the expression of NF-KB was significant lower than low-gradeintraepithelial neoplasia, low-grade intraepithelial neoplasia was significant higher thannormal mucosa.Conclusion Tissue types of gastric polyps were inflammatory polyps and mainly inantral, mainly single polyps. HP infection may be associated with gastric adenomatouspolyp formation; while PPI may have not effects on gastric polyps’ histological types.Adenomatous polyps may more common in colorectal polyps. Pathological type ofintestinal polyps, the size and number of polyps were associated with the malignantpolyps. For larger diameter sessile adenomas we should strengthen follow-up and timelyendoscopic resection. Long-term chronic inflammation can stimulate tumor formation.5-LOX、VEGF、PLGF and NF-kB have the consistenc expression in normal, hyperplasticcolon polyps, low-grade intraepithelial neoplasia, high-grade intraepithelial neoplasiaand colorectal cancer tissues. In adenoma may be mediated angiogenesis, inflammationunder consideration and5-LOX metabolic pathway. |
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