The Effect Of Qing Chang Lianyang Treating Ulcer Colitis And The Experiment Of Regulation Celluar Immunity And Cytokine (IL-10, IL-8, And TNF-α)

Objective The aim of the research is observing clinic curative of action about QingChangLianYang treating ulcer colitis, Analyze effect mechanism through regulation Cellular immunity and cytokine (IL-10, IL-8, and TNF-α).Method In clinical research, thirty patients of ulcer colitis were treated with QingChangLianYang prescription and therapeutic effects were compared with thirty patients with SASP and observing the curative effect of mucous membrane lesion. In experiment studies, observation the effects of QingChangLianYang on IL-8, IL-10, TNF-αon DSS rats, and detection CD4, CD8, and CD4/CD8, discuss the QingChangLianYang influence on immunity.Result Clinical research showed that in QingChangLianYang prescription group the total effective rate was 93.3%, while the total effective rate of SASP group is 70%, there has statistical significant about total effective of clinic curative, but no difference about patho-effective in two groups. And the experiment studies QingChangLianYang prescription group compare with the model group, can the notable restraint urges scorching cell factor IL-8, TNF-αcontents, move IL-10 contents up, can reduce CD4/CD8 ratio, adjusting the disorderly T cell thereby, and the QingChangLianYang prescription group restraint urging scorching cell factor IL-8, TNF-αcontents, raises or examines nature cell factor IL-10 contents effect obvious better than that SASP enema group.Discussion The investigation point out that QingChangLianYang prescription has fairly good clinic on ulcer colitis, and can obviously renovate intestines mucous membrane It’s the mechanism is connected with to restraining IL-8, TNF-αcontents, to moving nature cell factor IL-10 contents up to adjust sub group of disorderly T cell ratio.