Studies On The Pharmacy Of JG Aerosol

Epidemic influenza is a kind of acute respiratory tract infectious disease caused byinfluenza virus, influenza virus are easy to variety and human are empty of immunity tostrain, it is easy to break epidemic influenza. Chinese traditional medicine possess theadvantages of drug tolerance, low after effect and adverse reaction, but also have thegeneral effects on inhibition of virus replication and accommodating immunologic functionand improvement blood circulation and refrigeration analgesia and antibiotic antinflammation, it has unique advantages and wide long term potential in the area ofcontrolling influenza virus.Upper respiratory infection in the western medicine belongs to the category of commoncold. Cough is among the main symptom complex of lung system, and the reason of over90ï¼…acute upper respiratory infection is virus. After virus inrush upper respiratory tract,breeding at local at first, and causing damage on the organizations. It is the most importantto inhibit breeding at local to control upper respiratory infection. Chinese traditionalmedicine-spray could directly exterminate or inhibit pathogenic microbe inrushing local,and has the unique effect on controlling upper respiratory infection.Traditional Chinese medicine believed that Schizonepeta Tenuifolia is the wind drugsinto the blood system, and processes the effect of relieving toxin and muscles, sweatinghomeostasis after charring. It is pungent on its flavor, tepidity, and return liver, lung channel,and is used in common cold, headache, measles, rubella, and onset sores ulceration, curinguterine bleeding after charring. Research indicates that after inhibiting influenza virus bySchizonepeta Tenuifolia, the results show that Schizonepeta Tenuifolia and its compounds’ability of inhibiting influenza virus A3 is best, no matter administration first or latter. Itsuggested that Schizonepeta Tenuifolia had a certain extent of action on prevention andcuring, with similar effect by different medication.The research includes the preparation and the quality standard by orthgonal design andHPLC method, which is based on the analysis of the active parts in crude drug andpharmacodynamic selects, according to "the method of the new drug’s registration" and the claim of research of the fifth class of new Chinese drugs and natural drugs.The selection of three parts of extraction is investigated by the influenzavirus of type Amodel and auricle swelling model. The results show the volatile oil is the anti-cold part, onthe basis of which the best extraction technology has been selected by the orthgonal design.We reseach the quality control method of JK Soft-capsule and draw up the claim ofcrude drug, raw material and the quality standard of finished products. It gives the reliablebasis to the internal quality control of the preparation.By determing the LD₅₀ and studing the part pharmacology of the JK Soft-capsule, it issafe and effective in the treatment of chilling cold.After reserving sample and observed for 3months on the room temperature, checkedprogram were satisfactory （property, appreciation, determination）. Animalculum limit testcomplies with the pharmacopoeia of China inspection standard （edition 2000â…©â…¢C）, itshowed that the quality of spray was steady, after stored at room temperature for 3 months.