Study On Synthesis Of Apigenin -7-O-β-D- Glucuronide Of

Apigenin-7-O-β-D-glucuronopyranoside has anti-cancer and antioxidant activity. This paper presented a new synthetic route which selected Glucurolactone and Apigenin as starting material. The target compound was obtained in7-steps, including transesterification, protection, selective de-protection, bromination, condensation, hydrolysis and de-protection. The overall yield was29.8%. The optimized reaction and post-processing conditions were obtained through experimental parameters screening, such as, reaction reagent, solvent, reaction temperature, and reaction time, etc. The new synthetic route avoids the use of reagents and solvents which have toxicity and environmental contamination. And it is not only suitable for laboratory synthesis and scale-up, but also has the potential for industry production. Meantime, it may provide guarantee for the further biology activity and clinical trial study.