| Objective:To observe the compatibility and biological repair of a kind bioglass and NovaBone on rabbits groove type bone loss wounds. The wounds filled with the biological material, will be the structure of bone, and avoid the second operation. Methods:64rabbits are randomly allocate to postoperative4W,8W,12W,24W groups,16rabbits/group. Each of rabbits was made of models with femoral condyle bone defect, left part is filled with Dikang bioglass, and right part with NovaBone as controls, drawing blood at corresponding time point after operations, then detecting levels of serum calcium and phosphorus ions, having X-ray and observing the pathohistology of femur. Results:After operations, all groups have stable vital signs, regular food and doings, all can stand walk within one week and recover well; X-rays detect show implant material biodegraded and have obvious osteogenesis, bone developed in the main12weeks afteroperation, pasty and massive materials have no difference in promoting healing of the bone24weeks afteroperation. Levels of serum calcium ion decrease gradually, phosphorus decrease after a short period increasing slowly. Conclusions:The bioglass promotes osteogenesis effectively, especially with the filling effect to the groove type.,and shows a good effect in bone restoration and has well biological compatibility. |
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