Elastography And Clinical Research Serum Markers And Liver Biopsy Diagnosis Of Liver Fibrosis In Real-time Organization

[Objective] The study use the real-time tissue elastography and serological i ndexes contrasted with the fibrosis staging of the liver biopsy,to screen out the most diagnostic value of indexes, in order to provide a examination met hod that is noninvasive,the patient easy to accept, and good repeatability.It is can assess the degree of liver fibrosis in early stage,and conducive to p ositive intervpose the pathema to prevent it progress.[Methods],In the second affiliated hospital of kunming medical university gandanyi internal medicine, from March2011to February2012,screen eligible76hospitalized patients, male37cases, female39cases, minimum age12years old, biggest71years old, average age (42±14.805).All patients underwent the liver biopsy, that use1second of puncture method by the automatic biopsy needle of the American BARD, guided by ultrasound localization downward. And before the liver biopsy1or2days,all patients underwent the real-time tissue elastography to quantify the degree of liver fibrosis, and the serological index check:, hyaluronic acid,collagen type IV, type III procollagen, laminin, and transforming growth factor-β1, plateletderived growth factor, and to contrast with the fibrosis staging of the liver biopsy pathology statistical an,to alysis and evaluate the relationship between these indexes and the degree of hepatic fibrosis, and screen out the most valueable diagnostic indicators.[Results] Contrast LF of real-time tissue elastography and serological index with the stage of hepatic fibrosis, all their P＜0.05,it hass tatistically significant difference, and gradually rise with the degree of liver fibrosis. Through correlate and analysis these indexes between the two, all P=0.000＜0.05,having statistically significant difference.Further, the data is divided into two groups by the mid value to contrast with liver fibrosis S, all P＜0.05, having statistically significant difference. When LF is3.1or less, liver fibrosis stage is given priority to S1, LF＞3.1, liver fibrosis is given priority to with S2,3,4, in conformity with the pathological results. When HA, LN, IVC and PCIII, PDGF, TGFβ1respectively is66.5、70.5、59、116.6、28.3、665.4or less, liver fibrosis is given priority to S1; When were＞66.5、70.5、59、116.6、28.3、665.4, liver fibrosis is given priority to with S2,3,4. Area under the ROC curve for each indicator, LF＞0.9, HA and PCIII ranged between0.7and0.9, LN, IVC, PDGF and TGFβI between0.5and0.7.[Conclusion]1Real-time tissue elastography (RTE) and the degree of liver fibrosis was positively correlation, with increases with increasing of the degree of liver fibrosis, and LF＜≤3.1is mainly S1,＞3.1is given priority to with S2,3,4.2Serological indexes of HA, LN, IVC, PCIII, PDGF and TGF-β1, correlation with hepatic fibrosis were increased with the increase of degree of hepatic fibrosis. It can be used to indirectly assess the degree of liver fibrosis.3It is high accuracy of LF to diagnose of liver fibrosis.To HA, PCIII, the accuracy is medium; to LN, IVC, PDGF and TGF-β1, the accuracy is low.4Real-time tissue elastography is coincident with the stage of liver fibrosis pathological, it can be used to assess the degree of liver fibrosis in clinical, in that to avoid or reduce the chance of the liver biopsy, and is more suitable for follow-up observation.