Preparation And Quality Of Chinese Medicine Effervescent Tablets

Traditional Chinese medicine (TCM) effervescent tablets are composed of Evodia rutaecarpa, Folium artemisiae argyi, Rhizoma ligustici wallichii, Twotooth achyranthes root, Safflower, Chili. In this recipe the Evodia rutaecarpa is principal drug,and together with Folium artemisiae argyi, safflower and other ministerial drugs.While the six were combined, the effects of killing louse, dispeling stasis and dredging meridians, reducing swelling and pain.Treatment of varicose veins,peripheral neuritis,cold headache disease and so on, alleviating fatigue, raising body care function.Traditional Chinese medicine (TCM) effervescent tablet agent is medicinal herbs extract as the main raw material of traditional Chinese medicine preparations,after extracting prescription of Chinese herbal medicine effective components,then mixing with inorganic salt ions and effervescent agent in tablets.Early pharmacodynamics experiment indicates that the tablet can make the body temperature rise, effectively alleviate users’fatigue and has good effect to cold headache.The animal toxicology experiment and skin irritation and allergic experiments confirmed that TCM effervescent tablets are safe and effective.In order to improve the curative effect of Chinese medicine effervescent tablet agent and optimize the prescription of the medicinal herbs extraction:Evodia rutaecarpa is the main drug, Experiment of extracts of evodia rutaecarpa alkali optimization, make the maximum effective components and ensure the curative effect of bath agent;Artemisia argyi extract volatile oil,We prepare the volatile oil inclusion with the β-cyclodextrin to increase the water-soluble and stability of the volatile oil; We extracted rhizoma Iigustici wallichii and twotooth achyranthes root and concentrated the filtrate to get effective components; Safflower and Chili is extracted by ultrasonic method, we control the temperature to make the active ingredients are not destroyed.After the above processing medicinal active ingredients are centralized, a small amount of drugs can play a strong role.Medicinal materials according to the above method processing before adding inorganic salt ions and effervescing agent in tablets, the effervescent tablets in water can produce carbon dioxide, making tablets quickly split into smaller pieces and the contain medicinal ingredients can quickly dissolve.Effervescent tablets produce a large number of bubbles, increase the drug direct contact with the skin and play a better curative effect. In this research, prescription of the TCM effervescent tablets are selected by the orthogonal.We make score standard with sensory index and experiment index for effervescent tablets.With this score standard,we make multivariate study for the preparation of TCM effervescent tablets and with this help, we confirmed the best prescription and parameters.The TCM effervescent tablets is made of40%mixed drug proportion,50%effervescent agent,6%wetting agent and1%lubricant.According to the preparation general rule to the traditional Chinese medicine tablets request of Chinese Pharmacopoeia2010edition, We carry on the corresponding project inspection on the basis of experimental results. In this research, Evodia rutaecarpa and Safflower are identified by thin layer chromatography (TLC). The method is established for determining the content of evodia rutaecarpa alkali by High Performance Liquid Chromatography (HPLC)Traditional Chinese medicine (TCM) effervescent tablet is a kind of uniform light green fragrance solid, with a certain hardness, smooth surface, no miscellaneous spots and foreign body.The content of evodia rutaecarpa alkali in TCM effervescent tablet is not lower than13.24mg/g and10.28mg/g.And tablet of traits,pH value,hardness, disintegration time limit etc. are all need to be consistent with the preparation general rule to the traditional Chinese medicine tables request of Chinese Pharmacopoeia2010edition.The formulations stability studies showed that the TCM effervescent tablet is sensitive to light, in the long time high temperature also have certain effect. The results of Accelerated test and long-term test showed that there is no much change in the invested parameters when TCM effervescent tablet is in the package of powder coating aluminium film, and the preparation stability is satisfied.