Correlation And Determination Of Primary Biliary Cirrhosis Syndrome Analysis And Clinical Manifestations

Objective: to adopt methods that combined logistic regression analysisand multiple comparison analysis to find the correlation between TCMsyndrome type and liver and kidney function, blood coagulation and otherphysical and chemical indicators, further more,to explore the inherentlaws. And to establish discriminant equation of TCM syndrome types byadopting Fisher linear discriminant analysis method based on the commonsymptoms, signs and related physical and chemical indicators,used toauxiliarily guide the diagnosis of TCM syndrome type.Methods: recording the information which collected from the patients indigestion ward and infection outpatient department of the FirstAffiliated Hospital of Liaoning University of Traditional ChineseMedicine from2005.1-2012.6,and using logistic LR regression method toanalyse the correlation between above mentioned indicators and syndrometypes, then do the pairwise comparison among indicators of differentsyndromes and validate the credibility through cross-referring above twomethods.All common symptoms, signs, and physical and chemical indicatorsof the68patients are analysed the correlation and20significantvariables are screened, then the four TCM syndromes discriminantequations are established by stepwise regression method.Results:the research shows that the results of logistic regressionanalysis are basically identical with multiple comparison analysis.Italso establishs four discriminant equations with select indicators suchas tongue and pulse, yellow eyes, dark urine, liver palms or spider veins,peripheral edema, ALB, PTA, TBA by Fisher linear discriminant method,andit shows the predictive accuracy of equations are from73.7%to100%byback substituting variable values,the high accuracy proves discriminantsyndrome type can be used as an important reference.Tongue and pulse, yellow eyes, ALB, PTA discriminant permit core variables that have themost significant contribution to the value of the discriminant of TCMsyndromes.Conclusion:propagated with good of the predicted value, when the PTA, RBCmaintain at a high level, diagnosis as stagnation of liver-Qi withdeficiency of spleen is high,when the GGT is higher,the possibility ofsyndrome of dampness-heat is big while syndrome of water and blood stasisshould also be considered, when ALB, PTA treatment reduced obviouslyappropriate diagnose syndrome of water and blood stasis,at the same time,if TBA, WBC elevated, the diagnosis evidence of syndrome of water and bloodstasis is more fully.The four equations established on the basis of thescreened indicators are of high accuracy,can be used as an importantmethod and basis for guiding the differentiation of symptoms and signsfor classification of syndrome.