Menopausal Women Insomnia Syndrome, Related Research And Sex Hormone Levels

Objectives:To investigate the existence of the direct correlation between the sex hormones level and menopausal insomnia. To provide new ideas for the Traditional Chinese Medicine (TCM) treatment of menopausal insomnia if TCM syndrome and sex hormones are connected.Methods:The clinical cases observation table was used to collect outpatient menopausal women, who were divided into the control group and the insomnia group. The main collected contents included general information, Pittsburgh Sleep Quality Index, four diagnosis information and the sex hormone values obtained from the blood test of sex hormones. SPSS17was used for data statistics and analysis of the results.Results:All the menopausal insomnia women gave the scores of satisfaction of the s leep qual i ty at2point or3point. Howevre, almos t none of them used hypnot ic drugs, except2cases in this sample (4.6%of the total). The incidences of sleep problems of perimenopausal women (from high to low) were:night sleep disorder (100%), lack of sleep (90.5%), daytime dysfunction (85.7%), lower sleep efficiency (85.7%), difficulty in fal ling asleep (66.7%). And the postmenopausal women s were:lack of sleep (95.5%), night sleep disorder (90.9%), daytime dysfunction (90.9%), lower sleep efficiency (90.9%), difficulty in falling asleep (72.7%). PSQI and sex hormones were non linear correlation by the correlation analysis. In the component as difficulty in falling asleep, there is a statistical significance of the value of E2between the low points group and high points group (P=0.045<0.05). TCM syndromes of insomnia group from high to low were in this order:15cases of hyperactivity of fire due to yin deficiency syndrome (34.9%);9cases of liver depression transforming into fire syndrome (20.9%);8cases of phlegm-heat attacking internally syndrome (18.6%);7cases of heart-spleen deficiency syndrome (16.3%);4cases of heart-gallbladder Qi deficiency syndrome (9.3%). Liver depression transforming into fire syndrome was in the highest proportion among the perimenopausal women (33.3%); hyperactivity of fire due to yin deficiency syndrome was in the highest proportion among the postmenopausal women (50%). Compared with the control group, the level of E2of insomnia group was lower, but the difference was not statistically significant (P=0.088>0.05). The level of E2of hyperactivity of fire due to yin deficiency syndrome was lower than the control group, the difference was statistically significant (P=0.011>0.05). The level of LH of hyperactivity of fire due to yin deficiency syndrome was higher than the control group, the difference was statistically significant(P=0.024>0.05). Conclusion:Menopausal Insomnia is not entirely related to the changes of sex hormones. The level of E2of hyperactivity of fire due to yin deficiency syndrome reduces and the level of LH elevates significantly. The reduction of E2major impacts on extending the time to fall asleep.