Clinical Use Of Primary Insomnia Drug Law Real-world Research Methods

Objective:Based on the clinical history of Chinese medicine and clinical research data information sharing system technology platform acquisition, real-world application of research methods, summarized Professor Liu Yanjiao diagnosis and treatment of primary insomnia drug laws.Methods:Establish inclusion criteria and exclusion criteria of primary insomnia to screen the medical records, apply Chinese medical and clinical research information sharing system technology platform to record the medical records of primary insomnia and processing raw data, establish primary insomnia symptoms, medication database. Data mining analysis based on the use of different analytical target frequency analysis, complex network analysis, point mutual information analysis and other methods.Results:1.A total of187cases fit the case, the number of patients is121. Males50cases(26.7%), female137cases (73.3%). Age distribution:18-68years old, the average age of male is43.2and average age of female is46.0. Duration distribution:34cases within six months,9cases six months to1year,1year to10years107cases,30cases of10to20years,5cases of20to30years,2cases of more than30years.2.The treatment process totally using traditional Chinese medicine165flavor, herbs frequency statistics in the treatment of primary insomnia find the most commonly used herbs are:bupleurum root, Polygala, licorice, jujube seed, oyster, keel, Shi Changpu, Caulis Polygoni Multiflori, tangerine peel, bitter orange. The use of prescription276, which uses up to Cumian Fang1(96), Cumian Fang4(50) for promoting sleep. Through a complex network analysis, get the core drugs to treat this disease and the compatibility of complex network chart. The core of drugs:keel, oyster, Shi Changpu, Polygala, bupleurum root, Caulis Polygoni Multiflori; dried orange peel, licorice, citrus aurantium, Zhu Ru. And the drug mutual information value, according to the mutual information values in descending order, the top five for the keel and oysters (17.764), Shi Changpu (15.432), and Radix Polygalae Radix Polygalae and oysters (15.157), Radix Polygalae and keel (15.157), Radix Bupleuri and keel (15.028). Primary insomnia drugs second layer network graph, the core of drugs:Suanzaoren, Coptis, Jiao Shanzha, malt, rice, fried abalone, Jiang Banxia. Primary insomnia drugs third layer network graph, core drugs:Radix Paeoniae Alba, angelica, Poria, Radix Ophiopogonis, Cornus officinalis; Poria, lotus seeds, agrimony. According to the case and the scale to determine the four types of insomnia is difficulty falling asleep type in14cases, shorter sleep time type in11cases, middle easy up type in37cases,27cases of mixed type. Are the complex network chart. Among them, difficulty falling asleep insomnia core:keel, oysters, Shi Changpu, polygala root, bupleurum, radix ginseng, rushes, Caulis Polygoni multiflori. The intermediate wake up sleep core:tangerine peel, citrus, bamboo shavings, Coptis, licorice, jujube kernel, angelica, Poria, Radix ophiopogonis. To shorten sleep time sleep core prescription:tangerine peel, citrus, bamboo shavings, Coptis, licorice, jujube seed, malt, rice, fried coke hawthorn. Mixed type insomnia:core prescription:bupleurum, keel, oysters, Polygala, Shi Changpu, Caulis Polygoni Multiflori, rushes. Association frequency by pointwise mutual information method analysis of symptoms and medication rules get symptoms and medication and mutual information, one night to wake up link frequency and wild jujube kernel (93) and (37.1776) the highest value of mutual information. Through a complex network analysis of primary insomnia core symptoms are night wake up, sleep difficulties, dry mouth, usually cold, accompanied by symptoms of nocturnal frequent micturition, dry stool, always afraid of heat, night sweating, complex network chart symptoms and medication.Conclusion:the application of real world study method and sharing platform, based on traditional Chinese medicine in treating primary insomnia as the breakthrough point, from different angles, summarizes the regularity of Professor Liu Yanjiao on the treatment of primary insomnia, do the beneficial attempt for the application of real world study method.