Based On HIS Real World Research Methods And Research On The Laws Of The Drug In Patients With Coronary Heart Disease, Atrial Fibrillation

The First Part:Based on HIS realworld research method and it’s application in clinical efficacy evaluation of traditional Chinese medicineIn the real world of HIS platform for technology research has been in the national Chinese medicine clinical research base of applied medical institutions. As a clinical study of a new concept of traditional Chinese medicine, in the face of the characteristics of complex intervention, how to evaluate the clinical effect of traditional Chinese medicine,methodology is the biggest challenge. This article from the basic concept of ihs and real world research,the characteristics,introduction and analysis of the real world research methods, expounds its application in the clinical efficacy evaluation of traditional Chinese medicine at present.The Second Part : Based on HIS real world research methods research on the laws of the drug in patients with coronary heart diseaseatrial fibrillationObjective Choose the clinical diagnosis and treatment of hospitalized patients with coronary heart disease, atrial fibrillation data, is clear about in the real world general characteristics and developing regularity of hospitalized patients with coronary heart disease, atrial fibrillation, provide a reference for establishing a standardized coronary heart disease, atrial fibrillation in TCM diagnosis and treatment pattern, improve the level of clinical diagnosis and treatment.Methods Screening of hospitalized patients with established coronary heart disease, atrial fibrillation inclusion criteria and exclusion criteria, through the hospital information system, from a medical system and medical record system 2 affiliated hospital of shandong university of TCM disease section on January 1, 2014 to January 31, 2016 were hospitalized patient information. Will extract the basic information of patients and the diag- nostic information import EXCEL table and merge, from the diagnosis of the combined screening and contains "coronary heart disease" of patients; Com-plete screening,to get results. On the basis of patient ID to extract the drug use situation, import EXCEL table respectively. Descriptive sta- tistics with SPSS17.0 statistical analysis software to use excel auxiliary maps, with Liquorice software for complex network analysis and point mutual information analysis, looking for coronary heart disease, atrial fibril- ation core prescription and strong correlation between the two drugs.Result1.The general situation 466 cases of hospitalized patients with coronary heart disease, atrial fibrillation, male 231 cases(49.57%), female, 235 cases(50.43%); Aged30~95, median 74 years old, male patients with median 75 years old, female patients with median 73 years old; Women in 60~74 aged cases in hospital more than men, in hospital from 75~89 ages, the number of men slightly more than women; Hospitalization days 1~72 days, the median for 17 days, hospitalization days with 15 ~28 days most, does not change significantly from 2014 to 2015 in the hospital days.2.Using drugs regularity(1) Proprietary Chinese medicine 111 kinds of treatment process of the communist party of China use proprietary Chinese medicine. Use frequency of the top 10 Chinese patent medicine, in turn, for ginseng and astragalus injection,injection, Dan red injection, available kyushin pills, injection with salvia miltiorrhiza phenolic acids, and shensong yangxin capsule, dropping pill, and pulse yangxin pill stilbene yiqi, cough phlegm mixture, stilbene force strong heart capsule; Proprietary Chinese medicine according to the function classification, in the top five classes for activating blood circulation and nourishing Yin, clear heat, cough phlegm, runchang purge.(2)Western medicine Use 239 kinds of western medicine treatment process of the communist party of China. Use frequency of the top 10 of polarization liquid group,western medicine betaloc, low molecular heparin and aspirin, isosorbide mononitrate tablets(capsules) and clopidogrel bisulfate, rui shu cut statin pills, cefuroxime, Sammy injection, ammonia bromine injection, digoxin tablets; Western medicine according to the function classification in the top five, against myocardial ischemia, ventricular rate control,diuresis, regulating blood lipid.(3) Traditional Chinese medicine medicinal broth Treatment process using traditional Chinese medicine(TCM) 300. Frequency, frequency statistics, the traditional Chinese medicine treatment of coronary heart disease the most commonly used in the first 10 taste traditional Chinese medicine(TCM) for atrial fibrillation: rhizoma coptidis, radix astragali,radix ophiopogonis, rhizoma ligustici wallichii, dangshen, poria cocos, angelica, Fried zizyphus jujube kernel, radix rehmanniae, notoginseng powder, we can find that heart disease Ning Fang, vein for commonly used formula. Is obtained by complex network analysis, core prescription for the treatment of the disease: rhizoma coptidis, radix astragali,radix ophiopogonis, rhizoma ligustici wallichii, tuckahoe, angelica, dangshen, qing pinellia,Fried zizyphus jujube kernel, liquorice; Using point mutual information analysis, in addition to find dwarf lilyturf, fructus schisandrae, rhizoma coptidis, radix astragali,rhizoma coptidis, dangshen, codonopsis, radix ophiopogonis and rhizoma chuanxiong,rhizoma coptidis, radix angelicae sinensis, rhizoma ligustici wallichii, radix rehmanniae,fry zizyphus jujube kernel, giant knotweed, purple quartz coronary heart disease and atrial fibrillation commonly used drug compatibility between correlation intensity is higher, the coke hawthorn- bran divine comedy, solomonseal rhizome, radix trichosanthis, red ginseng, calcined oyster, cassia twig, dwarf lilyturf, vinegar rhizoma corydalis, radix ophiopogonis, main licorice, rhizoma coptidis compatibility relation intensity is high, also found that the compatibility of coke hawthorn- bran divina commedia correlation coefficient(10.38439), the largest higher than other special medicine on the correlation coefficient, coke hawthorn- bran divine comedy is also currently visible atrial fibrillation to commonly used medicines for treatment of the coronary heart disease.Conclusion1.Coronary heart disease patients with atrial fibrillation ratio is men and women, the elderly, hospitalization days tended to more than 15 days.2.Western medicine application conforms to the guidelines recommended; Using C omplex network and Point mutual information analysis of drug law, more objectively reflect the heart of hospital of shandong university of traditional Chinese medicine prescriptions of Chinese medicine treating coronary heart disease, atrial fibrillation, namely with qi and nourishing Yin, promoting blood circulation to remove blood stasis as the main therapeutic principle, along with the card with qi, eliminating phlegm, explored, clear heat, water, etc.