Study On Properties Of Organic Small Molecule Gel Based On Mint And Its Application

The supramolecular gel that consist of low-molecular weight gelators (LMWGs)is a kind of special materials, as they have the advantages of rapid response toexternal environmental stimulation, moleculars are easy to be synthesized, modifiedor biodegradable, relatively low cytotoxicity and thixotropic but self-healing. And sothey can be variously used in artificial intelligence materials, biological tissueengineering materials, sustained release, molecular devices, etc. In this thesis, threekinds of LMWGs based on (-)-menthol were designed and synthesized, we studied thegelation properties and structural characteristics of these gels in detail. Besides, wealso explore the application of the hydrogel as a universal antibacterial carrier. Thewhole paper contains two parts as following:1.(-)-Menthol based thixotropic hydrogel and its application as a universalantibacterial carrierWe designed and synthesized four kinds of compounds based on (-)-menthol,compound1could gelate aqueous ethanol solution with a certain ratio and compound2could form a stable hydrogel in pure water. The hydrogel2has good thixotropy andself-healing capability, besides, the gelator2has almost no cytotoxicity. Thecompound2could also gelate some confirmed antibaterial agents such as zinc acetateor common organic antibiotics such as soluble lincomycin, amoxicillin, etc. in such aunique way that the concentration of the antibacterial agents loaded into hydrogel canbe accurately tuned to a large extend, which may be more simple and effective thanother mixed or embedded methods. The antimicrobial susceptibility of the hydrogelsloaded with Zn2+or lincomycin is much more effective than that of the aqueoussolution tested by oxford cup method.2. A kind of (-)-menthol based organogel which can be formed at roomtemperatureOn the basis of the first part of work, as the (-)-menthol can be obtained easily, wedesigned and synthesized two kinds of (-)-menthol based compounds, linking withBoc-ethanediamine and ethanediamine. Compound5could gelate aqueous ethanolsolution with a certain ratio respectively at room temperature or after heating-cooling.The mechanism of the self-assembly process was investigated by means of IR, SEM,X-ray diffraction and rheological experiments. Even more, we explored the influenceof different volume ratio of mixed solvent in the aqueous ethanol solution on the formation of the organogel at room temperature.