Study On Metal-Free Difunctionalization Of Alkenes

In recent years, the direct difunctoinalazation of alkenes is an efficiency strategy for the synthesis of a series of organic compounds, which providing an effective way for a wide varity of organic functional molecules. Recent studies have demonstrated that many difunctoinalazation of alkenes were developed, such as heteroatom-heteroatom, carbon-carbon, carbon-heteroatom of alkenes. However, there are few studies about sulfuooximation and halogen amination of alkenes. This thesis describes these two transformations. This thesis is composed of three parts:1. The developments of transiton metal catalyzed and metal-free catalyzed difunctionalization of alkenes were summarized in detail. The scope of this review is pay attention to difunctionalization of alkenes catalyzed by Pd, Cu, Fe, Au, Ag catalysts and small organic molecules. The reactions are classified by the metal types of catalyst and introduced systematically. The content were introduced by the metal and nonmetal catalyzed.2. We described a novel tert-Butyl nitrite participated sulfuroximation of alkenes in detail. This reaction is started from simple olefin and sulfinic acid to construct various oximes. Meanwhile, the expansion of the reaction substrates and reaction mechanism were described in detail.3. We presented in detail a high-efficiency t-Butyl hypochlorite promoted the reaction of cyclization γ, δ-alkenyl hydrazone. In this reaction, we can obtain a high yield product of azomethine imine by employing γ,δ-alkenyl hydrazone as substrate, t-Butyl hypochlorite as chlorite source. We developed a metal-free, mild and highly efficient chlorite amination of alkenes, which according with the green chemistry and sustainable development etc.