Preparation Of FeNi 3 Particles And Its Application In Photothermal / Drug Synergistic Therapy And Nuclear Magnetic Resonance Imaging

In recent years, near-infrared light mediated light heat treatment technology, can carry on the targeted to the tumor tissue and in normal tissues has lower side effects, provides a new method for the treatment of tumor. In order to improve the efficiency of thermal destruction, we through the load anti-cancer drug doxorubicin chemotherapy, and chemotherapy and treatment of field synergy effect increases the damage of cancer cells, and by using near infrared imaging technology for real-time monitoring of the process of heat treatment. Nuclear magnetic resonance imaging(MRI) is a kind of ideal can provide auxiliary diagnosis for thermal treatment and real-time monitoring of imaging mode. This paper is devoted to the study has a good biocompatibility of the nanometer Fe Ni3 alloy materials, has obtained certain achievement.This paper explores Fe Ni3@DSPE-PEG/DOX for heat treatment(Photo Thermal Therapy, PTT), drug loading and magnetic resonance imaging(magnetic resonance imaging, magnetic resonance imaging) is feasible. Methods: With acetylacetone iron and nickel acetylacetonate as precursor, oil amine as the solvent and surfactant, thermal decomposition method is used to get uniform particle size of oil soluble Fe Ni3 nano alloy material, through ligand exchange method with polyethylene glycol(PEG) of phospholipids exchange oil amine molecules on the surface of the cover in Fe Ni3, get a Fe Ni3@DSPE-PEG.Adriamycin(doxorubicin, DOX) with hydrophobic hydrophobic interaction between load on Fe Ni3@DSPE-PEG, formed Fe Ni3@DSPE PEG/DOX.By synthetic iron nickel nanoparticles with TEM we know its good dispersibility and uniform particle size of 5.9 nm. Solution has good heat warming effect, and can load is a large amount of DOX; Under the condition of magnetic field of 0.5 T Fe Ni3@ DSPE-PEG relaxation rate is 50.5 m M-1?S-1;In vitro cytotoxicity test, cell survival rate is not increased with the increase of concentration of nano alloy material;Will Fe Ni3@DSPE-PEG/DOX with 4T1 cells incubated with 12 h, the power density is 0.6 W/cm2 of Near infrared laser Near-infrared(NIR) under the irradiation of 15 min, calculate the 4 t1 cells survival rate is only 65%; Fe Ni3@ DSPE-PEG through the tail vein injection by planting in the rats with breast cancer(4 t1) tumor, observed on the near infrared imager, observation alloy interrogation effect of nanometer materials in the region of the tumor, and with injection of Fe Ni3@ DSPE-PEG rats were compared.